HtpG contributes to Salmonella Typhimurium intestinal persistence in pigs - Archive ouverte HAL Access content directly
Journal Articles Veterinary Research Year : 2015

HtpG contributes to Salmonella Typhimurium intestinal persistence in pigs

Elin Verbrugghe
  • Function : Correspondent author
  • PersonId : 979606

Connectez-vous pour contacter l'auteur
Alexander van Parys
  • Function : Author
  • PersonId : 878230
Bregje Leyman
  • Function : Author
  • PersonId : 985126
Filip Boyen
  • Function : Author
Freddy Haesebrouck
  • Function : Author
  • PersonId : 883353
Frank Pasmans
  • Function : Author
  • PersonId : 883352


AbstractSalmonellaenterica subspecies enterica serovar Typhimurium (Salmonella Typhimurium) contamination of pork, is one of the major sources of human salmonellosis. The bacterium is able to persist and hide in asymptomatic carrier animals, generating a reservoir for Salmonella transmission to other animals and humans. Mechanisms involved in Salmonella persistence in pigs remain poorly understood. In the present study, we demonstrate that the SalmonellahtpG gene, encoding a homologue of the eukaryotic heat shock protein 90, contributes to Salmonella Typhimurium persistence in intestine-associated tissues of pigs, but not in the tonsils. HtpG does not seem to play an important role during the acute phase of infection. The contribution to persistence was shown to be associated with htpG-dependent Salmonella invasion and survival in porcine enterocytes and macrophages. These results reveal the role of HtpG as a virulence factor contributing to Salmonella persistence in pigs.
Fichier principal
Vignette du fichier
13567_2015_Article_261.pdf (914.92 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

hal-01341428 , version 1 (04-07-2016)



Elin Verbrugghe, Alexander van Parys, Bregje Leyman, Filip Boyen, Freddy Haesebrouck, et al.. HtpG contributes to Salmonella Typhimurium intestinal persistence in pigs. Veterinary Research, 2015, 46 (1), pp.118. ⟨10.1186/s13567-015-0261-5⟩. ⟨hal-01341428⟩


16 View
42 Download



Gmail Facebook Twitter LinkedIn More