In this paper, we consider nonnegative solutions of spatially heterogeneous Fisher-KPP type reaction-diffusion equations in the whole space. Under some assumptions on the initial conditions, including in particular the case of compactly supported initial conditions, we show that, above any arbitrary positive value, the solution is increasing in time at large times. Furthermore, in the one-dimensional case, we prove that, if the equation is homogeneous outside a bounded interval and the reaction is linear around the zero state, then the solution is time-increasing in the whole line at large times. The question of the monotonicity in time is motivated by a medical imagery issue.