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Communication Dans Un Congrès Année : 2015

Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis

Résumé

Microtubules, components of the cytosqueleton, play an important role in cell division, cell migration and thus in the cancer proccess through dynamic instability. Therefore they are an important target for anti-cancer treatment. Proper modelling of dynamic instability is a crucial tool to understand the mechanism of action of microtubule targeting agents. In this paper, we propose a new concept for GTP-tubulin hydrolysis which allow the model to accurately reproduce microtubule dynamics observed in vitro or in cells. This approach will be more appropriate to take study the effects of drugs.

Dates et versions

hal-01322761 , version 1 (27-05-2016)

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Ayuna Barlukova, Stéphane Honoré, Florence Hubert. Mathematical modeling of the microtubule dynamic instability: a new approch of GTP-tubulin hydrolysis. Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, Mar 2015, Paris, France. 4 p., ⟨10.1051/itmconf/20150500011⟩. ⟨hal-01322761⟩
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