Statistical mechanics of the Huxley-Simmons model - Archive ouverte HAL
Article Dans Une Revue Physical Review E Année : 2016

Statistical mechanics of the Huxley-Simmons model

M. Caruel

Résumé

The chemomechanical model of Huxley and Simmons (HS) [A. F. Huxley and R. M. Simmons, Nature 233, 533 (1971)] provides a paradigmatic description of mechanically induced collective conformational changes relevant in a variety of biological contexts, from muscles power-stroke and hair cell gating to integrin binding and hairpin unzipping. We develop a statistical mechanical perspective on the HS model by exploiting a formal analogy with a paramagnetic Ising model. We first study the equilibrium HS model with a finite number of elements and compute explicitly its mechanical and thermal properties. To model kinetics, we derive a master equation and solve it for several loading protocols. The developed formalism is applicable to a broad range of allosteric systems with mean-field interactions.
Fichier principal
Vignette du fichier
main.pdf (1.04 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01322113 , version 1 (26-05-2016)

Identifiants

Citer

M. Caruel, L. Truskinovsky. Statistical mechanics of the Huxley-Simmons model. Physical Review E , 2016, 93 (6), pp.062407. ⟨10.1103/PhysRevE.93.062407⟩. ⟨hal-01322113⟩
315 Consultations
196 Téléchargements

Altmetric

Partager

More