Palladium-Catalysed Synthesis of !-(Trifluoromethyl)styrenes by Means of Directed C–H Bond Functionalization
Résumé
We report the first introduction of 2-bromo-3,3,3-trifluoropropene (BTP) by directed C–H bond functionalization. The developed method gives straightforward access to !-(trifluoromethyl) styrene derivatives without prior prefunctionalization of the substrates. This palladium-catalysed transformation was applied to a broad range of substrates, and the corresponding trifluoromethylated products were obtained in good yields.
This approach represents an alternative pathway to the classical method previously used to access such molecules.