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Article Dans Une Revue European Journal of Organic Chemistry Année : 2016

Palladium-Catalysed Synthesis of !-(Trifluoromethyl)styrenes by Means of Directed C–H Bond Functionalization

Résumé

We report the first introduction of 2-bromo-3,3,3-trifluoropropene (BTP) by directed C–H bond functionalization. The developed method gives straightforward access to !-(trifluoromethyl) styrene derivatives without prior prefunctionalization of the substrates. This palladium-catalysed transformation was applied to a broad range of substrates, and the corresponding trifluoromethylated products were obtained in good yields. This approach represents an alternative pathway to the classical method previously used to access such molecules.

Dates et versions

hal-01321389 , version 1 (25-05-2016)

Identifiants

Citer

Qun Zhao, Tatiana Besset, Thomas Poisson, J.-P. Bouillon, Xavier Pannecoucke. Palladium-Catalysed Synthesis of !-(Trifluoromethyl)styrenes by Means of Directed C–H Bond Functionalization. European Journal of Organic Chemistry, 2016, 2016 (1), pp.76-82. ⟨10.1002/ejoc.201501217⟩. ⟨hal-01321389⟩
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