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Article Dans Une Revue Chemistry - A European Journal Année : 2016

Catalytic Enantioselective Synthesis of Halocyclopropanes

Résumé

A catalytic asymmetric synthesis of halocyclopropanes is described. The developed method is based on a carbenoid cyclopropanation of 2-haloalkenes with tertbutyl a-cyano-a-diazoacetate using a chiral rhodium catalyst that permits access to a broad range of highly functionalized chiral halocyclopropanes (F, Cl, Br, and I) in good yields, moderate diastereoselectivity, and excellent enantiomeric ratios. The reported methodology represents the first general catalytic enantioselective approach to halocyclopropanes.

Dates et versions

hal-01321309 , version 1 (25-05-2016)

Identifiants

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Amandine Pons, Pavel Ivashkin, Thomas Poisson, André B. Charette, Xavier Pannecoucke, et al.. Catalytic Enantioselective Synthesis of Halocyclopropanes. Chemistry - A European Journal, 2016, 22 (18), pp.6239-6242. ⟨10.1002/chem.201600649⟩. ⟨hal-01321309⟩
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