—Investigations of the feasibility of smart sensor in harsh environment is presented. This very first study takes place in the framework of the I_SMART European project. First approach on the feasibility of integration of the full system is introduced. This system will have to work in harsh environment in terms of temperature and radiations what makes necessary the development of specifications for operation and reliability of the components and the investigation of margins for the interplay of the components. Implementation of the analog conditioning chain is investigated where electrical performances have been validated at SPICE-level simulations.