Adaptive learning support for learners becomes very important in the context of increasing re-use of resources from heterogeneous and distributed learning repositories. This chapter presents OrPAF, an Adaptive Educational Hypermedia (AEHS) and web-based System which integrates semantic web models and technologies in order to achieve interoperability with e-learning systems. The key feature of OrPAF is the construction of adaptive hypermedia courses: both the course structure and the course content are dynamically generated and adapted to learners. On the one hand, a learning ontology is proposed to describe, at a meta-level, abstract characteristics of an e-learning system. This learning ontology is instantiated to construct learning models: domain model, learner model and pedagogical model. On the other hand, semantic annotations and a semantic relevance measure are proposed to improve the LOM metadata associated to learning resources in order to reuse and share them. The authors tested the prototype on learners in order to evaluate the usability of OrPAF and to determine the conceptual capabilities developed by learners who used it.