Environmental solutions for the sustainable production of bioactive natural products from the marine sponge Crambe crambe - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Science of the Total Environment Année : 2014

Environmental solutions for the sustainable production of bioactive natural products from the marine sponge Crambe crambe

Résumé

Crambe crambe is a Mediterranean marine sponge known to produce original natural substances belonging to two families of guanidine alkaloids, namely crambescins and crambescidins, which exhibit cytotoxic and antiviral activities. These compounds are therefore considered as potential anticancer drugs. The present study focuses on the environmental assessment of a novel in vivo process for the production of pure crambescin and crambescidin using sponge specimens cultured in aquarium. The assessment was performed following the ISO 14040 standard and extended from the production of the different mass and energy flows to the system to the growth of the sponge in indoor aquarium and further periodic extraction and purification of the bioactive compounds. According to the results, the two stages that have a remarkable contribution to all impact categories are the purification of the bioactive molecules followed by the maintenance of the sponge culture in the aquarium. Among the involved activities, the production of the chemicals (particularly methanol) together with the electricity requirements (especially due to the aquarium lighting) are responsible for up to 90% of the impact in most of the assessed categories. However, the contributions of other stages to the environmental burdens, such as the collection of sponges, considerably depend on the assumptions made during the inventory stage. The simulation of alternative scenarios has led to propose improvement alternatives that may allow significant reductions ranging from 20% to 70%, mainly thanks to the reduction of electricity requirements as well as the partial reuse of methanol.
Fichier principal
Vignette du fichier
Perez-Lopez__SciTotEnviron_Environmental.solutions.bioproducts.C.crambe_Manuscript_R1.pdf (574.27 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01284801 , version 1 (19-01-2017)

Identifiants

Citer

Paula Perez-Lopez, E. Ternon, Sara Gonzalez-Garcia, Grégory Genta-Jouve, Gumersindo Feijoo, et al.. Environmental solutions for the sustainable production of bioactive natural products from the marine sponge Crambe crambe. Science of the Total Environment, 2014, 475, pp.71-82. ⟨10.1016/j.scitotenv.2013.12.068⟩. ⟨hal-01284801⟩
218 Consultations
246 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More