Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma - Archive ouverte HAL
Journal Articles British Journal of Cancer Year : 2016

Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma

Abstract

Background: Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. The constitutive expression of HIF-1α in MM suggests that inhibition of HIF-1α-mediated transcription represents an interesting target in MM. Methods: As p300 is a crucial co-activator of hypoxia-inducible transcription, disrupting the complex HIF-1α/p300 to target HIF activity appears to be an attractive strategy. Results: We reported that chetomin, an inhibitor of HIF-1α/p300 interaction, exhibits antitumour activity in human myeloma cell lines and primary MM cells from patients. Conclusions: Our data suggest that chetomin may be of clinical value in MM and especially for patients characterised by a high EP300/HIF-1α expression and a poor prognosis.
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hal-01284314 , version 1 (31-05-2022)

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Elena Viziteu, Camille Grandmougin, Harmut Goldschmidt, Anja Seckinger, Dirk Hose, et al.. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma. British Journal of Cancer, 2016, 114 (5), pp.519-523. ⟨10.1038/bjc.2016.20⟩. ⟨hal-01284314⟩
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