Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma - Archive ouverte HAL
Article Dans Une Revue British Journal of Cancer Année : 2016

Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma

Résumé

Background: Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. The constitutive expression of HIF-1α in MM suggests that inhibition of HIF-1α-mediated transcription represents an interesting target in MM. Methods: As p300 is a crucial co-activator of hypoxia-inducible transcription, disrupting the complex HIF-1α/p300 to target HIF activity appears to be an attractive strategy. Results: We reported that chetomin, an inhibitor of HIF-1α/p300 interaction, exhibits antitumour activity in human myeloma cell lines and primary MM cells from patients. Conclusions: Our data suggest that chetomin may be of clinical value in MM and especially for patients characterised by a high EP300/HIF-1α expression and a poor prognosis.
Fichier principal
Vignette du fichier
bjc201620.pdf (689.3 Ko) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-01284314 , version 1 (31-05-2022)

Licence

Identifiants

Citer

Elena Viziteu, Camille Grandmougin, Harmut Goldschmidt, Anja Seckinger, Dirk Hose, et al.. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma. British Journal of Cancer, 2016, 114 (5), pp.519-523. ⟨10.1038/bjc.2016.20⟩. ⟨hal-01284314⟩
61 Consultations
50 Téléchargements

Altmetric

Partager

More