In this day and age, firms compete by the skills and knowledge of their employees to deliver a range of customized solutions to meet their clients’ needs. Knowledgeable workers thereby play a pivotal role in today’s knowledge-based economy. In knowledge-intensive business service (KIBS) firms, service providers exchange explicit knowledge with service customers through various delivery channels. Information and communication technologies have led to the development of various delivery channels to provide e-services to customers and, consequently, the emergence of digital ecosystems fostering the flourishing of knowledge-intensive firms. In this paper, we study the development of digital ecosystems of business services. We particularly examine the design of the digital business ecosystem as a holistic system consisting of distributed and fine-grained elements, known as service systems. Based on the challenging characteristics of services, a service system exhibits its computational features in terms of Software-as-a-Service components and exchanges business knowledge encapsulated as business artifacts.