A characterization of the Moroccan oil shale was carried out to determine the mineralogical and chemical characteristics. Thermal analysis, x-ray diffraction and infrared techniques were used to study the thermal and the structure behaviors of the Moroccan oil shale from Tanger (OST). The TG analysis showed that the investigated mineral exhibited about 8% as total mass loss containing up 80wt.% of quartz-SiO2 with less CaO content (\textless1%). Batch adsorption experiments were conducted to investigate the removal of ciprofloxacin antibiotic from wastewater by addition of OST shale. The best adsorption was obtained with dried OST and calcined at 550°C, which are promising materials for antibiotic removal.