<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01266945</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-18T19:13:09+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial</title>
            <author role="aut">
              <persName>
                <forename type="first">Shady</forename>
                <surname>Kotb</surname>
              </persName>
              <idno type="halauthorid">852743-0</idno>
              <affiliation ref="#struct-224716"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alexandre</forename>
                <surname>Detappe</surname>
              </persName>
              <email type="md5">650054cf9266e1b4b5514d696ed10c28</email>
              <email type="domain">icans.eu</email>
              <idno type="idhal" notation="numeric">772112</idno>
              <idno type="halauthorid" notation="string">852747-772112</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9364-1621</idno>
              <affiliation ref="#struct-224716"/>
              <affiliation ref="#struct-412087"/>
              <affiliation ref="#struct-178714"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">François</forename>
                <surname>Lux</surname>
              </persName>
              <idno type="halauthorid">516504-0</idno>
              <affiliation ref="#struct-224716"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florence</forename>
                <surname>Appaix</surname>
              </persName>
              <idno type="halauthorid">246423-0</idno>
              <affiliation ref="#struct-1069706"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Emmanuel</forename>
                <forename type="middle">L.</forename>
                <surname>Barbier</surname>
              </persName>
              <email type="md5">a6a69a3f5e2c995317be82a807de732a</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">emmanuel-barbier</idno>
              <idno type="idhal" notation="numeric">745767</idno>
              <idno type="halauthorid" notation="string">120190-745767</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/E-6302-2011</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4952-1240</idno>
              <idno type="IDREF">https://www.idref.fr/120242079</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/E-6302-2011</idno>
              <affiliation ref="#struct-1069706"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Vu-Long</forename>
                <surname>Tran</surname>
              </persName>
              <idno type="halauthorid">991729-0</idno>
              <affiliation ref="#struct-224716"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie</forename>
                <surname>Plissonneau</surname>
              </persName>
              <idno type="halauthorid">991730-0</idno>
              <affiliation ref="#struct-224716"/>
              <affiliation ref="#struct-178714"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Hélène</forename>
                <surname>Gehan</surname>
              </persName>
              <idno type="halauthorid">991731-0</idno>
              <affiliation ref="#struct-224716"/>
              <affiliation ref="#struct-178714"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Florence</forename>
                <surname>Lefranc</surname>
              </persName>
              <idno type="halauthorid">805645-0</idno>
              <affiliation ref="#struct-245449"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Rodriguez-Lafrasse</surname>
              </persName>
              <email type="md5">9b087e46a997ad389d0c1f53ca90ca0b</email>
              <email type="domain">adm.univ-lyon1.fr</email>
              <idno type="idhal" notation="numeric">854059</idno>
              <idno type="halauthorid" notation="string">227490-854059</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9670-1853</idno>
              <idno type="IDREF">https://www.idref.fr/134232429</idno>
              <idno type="VIAF">https://viaf.org/viaf/54250456</idno>
              <idno type="ISNI">http://isni.org/isni/0000000000350968</idno>
              <affiliation ref="#struct-353860"/>
              <affiliation ref="#struct-2"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Camille</forename>
                <surname>Verry</surname>
              </persName>
              <idno type="idhal" notation="numeric">765022</idno>
              <idno type="halauthorid" notation="string">592130-765022</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9362-7624</idno>
              <affiliation ref="#struct-97332"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ross</forename>
                <surname>Berbeco</surname>
              </persName>
              <idno type="halauthorid">852748-0</idno>
              <affiliation ref="#struct-412087"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Olivier</forename>
                <surname>Tillement</surname>
              </persName>
              <email type="md5">d26ee86cbd66f4cbd3451e72f3db2e4e</email>
              <email type="domain">pcml.univ-lyon1.fr</email>
              <idno type="idhal" notation="numeric">938819</idno>
              <idno type="halauthorid" notation="string">177859-938819</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7166-6537</idno>
              <idno type="IDREF">https://www.idref.fr/085752002</idno>
              <affiliation ref="#struct-224716"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Lucie</forename>
                <surname>Sancey</surname>
              </persName>
              <email type="md5">d0350c3073f6f337b21427fd3d74a43b</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">lucie-sancey</idno>
              <idno type="idhal" notation="numeric">179893</idno>
              <idno type="halauthorid" notation="string">5256-179893</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0084-3775</idno>
              <idno type="IDREF">https://www.idref.fr/110676858</idno>
              <affiliation ref="#struct-224716"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Béatrice</forename>
                <surname>Rayet</surname>
              </persName>
              <email type="md5">1f7efd8a83567b02f91e70c1cafdf6ba</email>
              <email type="domain">creatis.insa-lyon.fr</email>
            </editor>
            <funder ref="#projanr-25732"/>
            <funder ref="#projanr-38020"/>
            <funder ref="#projanr-49807"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2016-02-03 15:53:57</date>
              <date type="whenModified">2026-03-27 19:20:06</date>
              <date type="whenReleased">2016-02-04 08:07:09</date>
              <date type="whenProduced">2016</date>
              <date type="whenEndEmbargoed">2016-02-03</date>
              <ref type="file" target="https://hal.science/hal-01266945v1/document">
                <date notBefore="2016-02-03"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-01266945v1/file/Kotb%20et%20al%20.pdf" id="file-1266945-1347790">
                <date notBefore="2016-02-03"/>
              </ref>
              <ref type="externalLink" target="http://www.thno.org/v06p0418.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="180336">
                <persName>
                  <forename>Béatrice</forename>
                  <surname>Rayet</surname>
                </persName>
                <email type="md5">1f7efd8a83567b02f91e70c1cafdf6ba</email>
                <email type="domain">creatis.insa-lyon.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01266945</idno>
            <idno type="halUri">https://hal.science/hal-01266945</idno>
            <idno type="halBibtex">kotb:hal-01266945</idno>
            <idno type="halRefHtml">&lt;i&gt;Theranostics&lt;/i&gt;, 2016, 6 (3), pp.418-427. &lt;a target="_blank" href="https://dx.doi.org/10.7150/thno.14018"&gt;&amp;#x27E8;10.7150/thno.14018&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Theranostics, 2016, 6 (3), pp.418-427. &amp;#x27E8;10.7150/thno.14018&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-1266945-1347790"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="IN2P3">Institut National de Physique Nucléaire et de Physique des Particules</idno>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
            <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno>
            <idno type="stamp" n="PRIMES">Physics, Radiobiology, Medical Imaging, and Simulation (PRIMES)</idno>
            <idno type="stamp" n="PRIMES_WP3" corresp="PRIMES">WP3: Radiobiologie, instrumentation et modèles pour une thérapie innovante</idno>
            <idno type="stamp" n="ILM" corresp="UNIV-LYON1">Institut Lumière Matière</idno>
            <idno type="stamp" n="IP2I" corresp="UNIV-LYON1">Institut de Physique des 2 Infinis de Lyon</idno>
            <idno type="stamp" n="UDL">UDL</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="PHABIO" corresp="IP2I">PRISME_PHABIO</idno>
            <idno type="stamp" n="UGA-COMUE">Université Grenoble Alpes [2016-2019]</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Gadolinium-Based Nanoparticles and Radiation Therapy for Multiple Brain Melanoma Metastases: Proof of Concept before Phase I Trial</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Shady</forename>
                    <surname>Kotb</surname>
                  </persName>
                  <idno type="halauthorid">852743-0</idno>
                  <affiliation ref="#struct-224716"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alexandre</forename>
                    <surname>Detappe</surname>
                  </persName>
                  <email type="md5">650054cf9266e1b4b5514d696ed10c28</email>
                  <email type="domain">icans.eu</email>
                  <idno type="idhal" notation="numeric">772112</idno>
                  <idno type="halauthorid" notation="string">852747-772112</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9364-1621</idno>
                  <affiliation ref="#struct-224716"/>
                  <affiliation ref="#struct-412087"/>
                  <affiliation ref="#struct-178714"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">François</forename>
                    <surname>Lux</surname>
                  </persName>
                  <idno type="halauthorid">516504-0</idno>
                  <affiliation ref="#struct-224716"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florence</forename>
                    <surname>Appaix</surname>
                  </persName>
                  <idno type="halauthorid">246423-0</idno>
                  <affiliation ref="#struct-1069706"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Emmanuel</forename>
                    <forename type="middle">L.</forename>
                    <surname>Barbier</surname>
                  </persName>
                  <email type="md5">a6a69a3f5e2c995317be82a807de732a</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">emmanuel-barbier</idno>
                  <idno type="idhal" notation="numeric">745767</idno>
                  <idno type="halauthorid" notation="string">120190-745767</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/E-6302-2011</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4952-1240</idno>
                  <idno type="IDREF">https://www.idref.fr/120242079</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/E-6302-2011</idno>
                  <affiliation ref="#struct-1069706"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Vu-Long</forename>
                    <surname>Tran</surname>
                  </persName>
                  <idno type="halauthorid">991729-0</idno>
                  <affiliation ref="#struct-224716"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie</forename>
                    <surname>Plissonneau</surname>
                  </persName>
                  <idno type="halauthorid">991730-0</idno>
                  <affiliation ref="#struct-224716"/>
                  <affiliation ref="#struct-178714"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Hélène</forename>
                    <surname>Gehan</surname>
                  </persName>
                  <idno type="halauthorid">991731-0</idno>
                  <affiliation ref="#struct-224716"/>
                  <affiliation ref="#struct-178714"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Florence</forename>
                    <surname>Lefranc</surname>
                  </persName>
                  <idno type="halauthorid">805645-0</idno>
                  <affiliation ref="#struct-245449"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Rodriguez-Lafrasse</surname>
                  </persName>
                  <email type="md5">9b087e46a997ad389d0c1f53ca90ca0b</email>
                  <email type="domain">adm.univ-lyon1.fr</email>
                  <idno type="idhal" notation="numeric">854059</idno>
                  <idno type="halauthorid" notation="string">227490-854059</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9670-1853</idno>
                  <idno type="IDREF">https://www.idref.fr/134232429</idno>
                  <idno type="VIAF">https://viaf.org/viaf/54250456</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000000350968</idno>
                  <affiliation ref="#struct-353860"/>
                  <affiliation ref="#struct-2"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Camille</forename>
                    <surname>Verry</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">765022</idno>
                  <idno type="halauthorid" notation="string">592130-765022</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9362-7624</idno>
                  <affiliation ref="#struct-97332"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ross</forename>
                    <surname>Berbeco</surname>
                  </persName>
                  <idno type="halauthorid">852748-0</idno>
                  <affiliation ref="#struct-412087"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Olivier</forename>
                    <surname>Tillement</surname>
                  </persName>
                  <email type="md5">d26ee86cbd66f4cbd3451e72f3db2e4e</email>
                  <email type="domain">pcml.univ-lyon1.fr</email>
                  <idno type="idhal" notation="numeric">938819</idno>
                  <idno type="halauthorid" notation="string">177859-938819</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7166-6537</idno>
                  <idno type="IDREF">https://www.idref.fr/085752002</idno>
                  <affiliation ref="#struct-224716"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Lucie</forename>
                    <surname>Sancey</surname>
                  </persName>
                  <email type="md5">d0350c3073f6f337b21427fd3d74a43b</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">lucie-sancey</idno>
                  <idno type="idhal" notation="numeric">179893</idno>
                  <idno type="halauthorid" notation="string">5256-179893</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0084-3775</idno>
                  <idno type="IDREF">https://www.idref.fr/110676858</idno>
                  <affiliation ref="#struct-224716"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">75392</idno>
                <idno type="issn">1838-7640</idno>
                <title level="j">Theranostics</title>
                <imprint>
                  <publisher>Ivyspring International Publisher</publisher>
                  <biblScope unit="volume">6</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">418-427</biblScope>
                  <date type="datePub">2016</date>
                </imprint>
              </monogr>
              <idno type="doi">10.7150/thno.14018</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">personalized medicine</term>
                <term xml:lang="en">imaged-guided therapy</term>
                <term xml:lang="en">nanoparticles</term>
                <term xml:lang="en">brain metastases</term>
                <term xml:lang="en">radiation therapy</term>
                <term xml:lang="en">radiosensitizer</term>
                <term xml:lang="en">AGuIX</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.can">Life Sciences [q-bio]/Cancer</classCode>
              <classCode scheme="halDomain" n="phys.phys.phys-med-ph">Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Nanoparticles containing high-Z elements are known to boost the efficacy of radiation therapy. Gadolinium (Gd) is particularly attractive because this element is also a positive contrast agent for MRI, which allows for the simultaneous use of imaging to guide the irradiation and to delineate the tumor. In this study, we used the Gd-based nanoparticles, AGuIX®. After intravenous injection into animals bearing B16F10 tumors, some nanoparticles remained inside the tumor cells for more than 24 hours, indicating that a single administration of nanoparticles might be sufficient for several irradiations. Combining AGuIX® with radiation therapy increases tumor cell death, and improves the life spans of animals bearing multiple brain melanoma metastases. These results provide pre-clinical proof-of-concept for a phase I clinical trial.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-224716" status="VALID">
          <idno type="IdRef">17806890X</idno>
          <idno type="ISNI">0000000403844911</idno>
          <idno type="RNSR">201320570G</idno>
          <idno type="ROR">0323bey33</idno>
          <orgName>Institut Lumière Matière [Villeurbanne]</orgName>
          <orgName type="acronym">ILM</orgName>
          <date type="start">2013-01-01</date>
          <desc>
            <address>
              <addrLine>UMR5306 CNRS Université Claude Bernard Lyon 1 Domaine Scientifique de La Doua Bâtiment Kastler, 10 rue Ada Byron 69622 Villeurbanne CEDEX, Franc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ilm.univ-lyon1.fr/index.php</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation name="UMR5306" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-412087" status="INCOMING">
          <orgName>Department of Radiation Oncology</orgName>
          <desc>
            <address>
              <country key="US"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-130467" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-178714" status="INCOMING">
          <orgName>Nano-H SAS</orgName>
          <desc>
            <address>
              <addrLine>38070 Saint-Quentin Fallavier</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-345122" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-1069706" status="OLD">
          <idno type="IdRef">184664446</idno>
          <idno type="ISNI">0000000404293736</idno>
          <idno type="RNSR">200716488W</idno>
          <idno type="ROR">https://ror.org/04as3rk94</idno>
          <orgName>[GIN] Grenoble Institut des Neurosciences</orgName>
          <orgName type="acronym">GIN</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Site Santé - Bâtiment Edmond J. Safra - Chemin Fortuné Ferrini 38706 La Tronche Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://neurosciences.univ-grenoble-alpes.fr/</ref>
          </desc>
          <listRelation>
            <relation name="U1216" active="#struct-303623" type="direct"/>
            <relation active="#struct-445543" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-245449" status="INCOMING">
          <orgName>Department of Neurosurgery, Erasmus University Hospital</orgName>
          <desc>
            <address>
              <addrLine>Brussels</addrLine>
              <country key="BE"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-358692" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-353860" status="VALID">
          <idno type="ROR">https://ror.org/023xgd207</idno>
          <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName>
          <orgName type="acronym">CHLS</orgName>
          <desc>
            <address>
              <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-2" status="OLD">
          <idno type="IdRef">083864520</idno>
          <idno type="RNSR">199512096Z</idno>
          <orgName>Institut de Physique Nucléaire de Lyon</orgName>
          <orgName type="acronym">IPNL</orgName>
          <date type="start">1971-01-01</date>
          <date type="end">2019-06-30</date>
          <desc>
            <address>
              <addrLine>Campus LyonTech-la DouaBâtiment Paul DIRAC4 Rue Enrico Fermi69622 Villeurbanne Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ipnl.in2p3.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-194495" type="direct"/>
            <relation active="#struct-301088" type="indirect"/>
            <relation active="#struct-300046" type="direct"/>
            <relation name="UMR5822 / UMR6422" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-97332" status="OLD">
          <orgName>Université Grenoble Alpes - UFR Médecine</orgName>
          <orgName type="acronym">UGA UFRM</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci - 38706 La Tronche cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://secteur-sante.univ-grenoble-alpes.fr/medecine/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-445543" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-194495" status="VALID">
          <idno type="IdRef">026402823</idno>
          <idno type="ISNI">0000000121686185</idno>
          <idno type="ROR">https://ror.org/029brtt94</idno>
          <orgName>Université Claude Bernard Lyon 1</orgName>
          <orgName type="acronym">UCBL</orgName>
          <desc>
            <address>
              <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lyon1.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301088" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-301088" status="VALID">
          <idno type="ROR">https://ror.org/01rk35k63</idno>
          <orgName>Université de Lyon</orgName>
          <desc>
            <address>
              <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-lyon.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-130467" status="VALID">
          <idno type="ROR">https://ror.org/03wevmz92</idno>
          <orgName>Harvard Medical School [Boston]</orgName>
          <orgName type="acronym">HMS</orgName>
          <desc>
            <address>
              <addrLine>25 Shattuck Street Boston, MA 02115</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">http://www.hms.harvard.edu</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-345122" status="INCOMING">
          <orgName>Nano-H SAS</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-445543" status="OLD">
          <idno type="IdRef">188399275</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes [2016-2019]</orgName>
          <orgName type="acronym">UGA [2016-2019]</orgName>
          <date type="start">2016-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-358692" status="INCOMING">
          <orgName>Erasmus University Hospital</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300046" status="VALID">
          <idno type="IdRef">028227875</idno>
          <idno type="ISNI">0000000106643574</idno>
          <idno type="ROR">https://ror.org/03fd77x13</idno>
          <orgName>Institut National de Physique Nucléaire et de Physique des Particules du CNRS</orgName>
          <orgName type="acronym">IN2P3</orgName>
          <desc>
            <address>
              <addrLine>CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 rue Michel-Ange75794 PARIS CEDEX 16 - France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://in2p3.cnrs.fr</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-25732" status="VALID">
          <idno type="anr">ANR-11-IDEX-0007</idno>
          <orgName>Avenir L.S.E.</orgName>
          <desc>PROJET AVENIR LYON SAINT-ETIENNE</desc>
          <date type="start">2011</date>
        </org>
        <org type="anrProject" xml:id="projanr-38020" status="VALID">
          <idno type="anr">ANR-11-INBS-0006</idno>
          <idno type="program">Infrastructures</idno>
          <orgName>FLI</orgName>
          <desc>France Life Imaging</desc>
          <date type="start">2011</date>
        </org>
        <org type="anrProject" xml:id="projanr-49807" status="VALID">
          <idno type="anr">ANR-11-LABX-0063</idno>
          <orgName>PRIMES</orgName>
          <desc>Physique, Radiobiologie, Imagerie Médicale et Simulation</desc>
          <date type="start">2011</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>