Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models - Archive ouverte HAL
Article Dans Une Revue Scientific Reports Année : 2015

Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models

Marion Gillet
  • Fonction : Auteur

Résumé

Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.
Fichier principal
Vignette du fichier
srep19399.pdf (633.75 Ko) Télécharger le fichier
Origine Publication financée par une institution
Loading...

Dates et versions

hal-01263911 , version 1 (03-02-2016)

Licence

Identifiants

Citer

S. Miquel, R. Martín, A. Lashermes, Marion Gillet, M. Meleine, et al.. Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models. Scientific Reports, 2015, 6, pp.19399. ⟨10.1038/srep19399⟩. ⟨hal-01263911⟩
469 Consultations
156 Téléchargements

Altmetric

Partager

More