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Journal Articles Breast Cancer Research and Treatment Year : 2013

Metabolic syndrome and hepatocellular carcinoma risk

F. Turati
  • Function : Author
R. Talamini
  • Function : Author
C. Pelucchi
  • Function : Author
J. Polesel
  • Function : Author
Sophie Franceschi-Messant
  • Function : Author
A. Crispo
  • Function : Author
F. Izzo
  • Function : Author
C. La Vecchia
  • Function : Author
M. Montella
  • Function : Author

Abstract

BACKGROUND: Hepatocellular carcinoma (HCC) has been associated to diabetes and obesity, but a possible association with the metabolic syndrome (MetS) and its potential interaction with hepatitis is open to discussion. METHODS: We analysed data from an Italian case-control study, including 185 HCC cases and 404 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed from unconditional logistic regression models. RESULTS: Among the MetS components, diabetes and obesity (i.e, body mass index (BMI)>/=30 kg m(-2)) were positively associated to HCC risk, with ORs of 4.33 (95% CI, 1.89-9.86) and 1.97 (95% CI, 1.03-3.79), respectively. The ORs for the MetS were 4.06 (95% CI, 1.33-12.38) defining obesity as BMI>/=25, and 1.92 (95% CI, 0.38-9.76) defining it as BMI>/=30. The risk increased with the number of MetS components, up to an almost four-fold excess risk among subjects with >/=2 MetS factors. Among subjects without chronic infection with hepatitis B and/or C, the OR for those with >/=2 MetS components was over six-fold elevated. There was no consistent association in subjects with serological evidence of hepatitis B and/or C infection. CONCLUSION: This study found that the risk of HCC increases with the number of MetS components in subjects not chronically infected with hepatitis viruses.

Dates and versions

hal-01261747 , version 1 (25-01-2016)

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F. Turati, R. Talamini, C. Pelucchi, J. Polesel, Sophie Franceschi-Messant, et al.. Metabolic syndrome and hepatocellular carcinoma risk. Breast Cancer Research and Treatment, 2013, 108 (1), pp.222-8. ⟨10.1038/bjc.2012.492⟩. ⟨hal-01261747⟩

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