Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea. - Archive ouverte HAL
Article Dans Une Revue Development (Cambridge, England) Année : 2015

Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea.

Victor Vendrell
  • Fonction : Auteur
Iris López-Hernández
  • Fonction : Auteur
María Beatriz Durán Alonso
  • Fonction : Auteur
Ana Feijoo-Redondo
  • Fonction : Auteur
Gina Abello
  • Fonction : Auteur
Héctor Gálvez
  • Fonction : Auteur
Fernando Giráldez
  • Fonction : Auteur
Thomas Schimmang
  • Fonction : Auteur

Résumé

Transcriptional regulatory networks are essential during the formation and differentiation of organs. The transcription factor N-myc is required for proper morphogenesis of the cochlea and to control correct patterning of the organ of Corti. We show here that the Otx2 gene, a mammalian ortholog of the Drosophila orthodenticle homeobox gene, is a crucial target of N-myc during inner ear development. Otx2 expression is lost in N-myc mouse mutants, and N-myc misexpression in the chick inner ear leads to ectopic expression of Otx2. Furthermore, Otx2 enhancer activity is increased by N-myc misexpression, indicating that N-myc may directly regulate Otx2. Inactivation of Otx2 in the mouse inner ear leads to ectopic expression of prosensory markers in non-sensory regions of the cochlear duct. Upon further differentiation, these domains give rise to an ectopic organ of Corti, together with the re-specification of non-sensory areas into sensory epithelia, and the loss of Reissner's membrane. Therefore, the Otx2-positive domain of the cochlear duct shows a striking competence to develop into a mirror-image copy of the organ of Corti. Taken together, these data show that Otx2 acts downstream of N-myc and is essential for patterning and spatial restriction of the sensory domain of the mammalian cochlea.
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Dates et versions

hal-01252894 , version 1 (08-01-2016)

Identifiants

  • HAL Id : hal-01252894 , version 1
  • PUBMED : 26160903

Citer

Victor Vendrell, Iris López-Hernández, María Beatriz Durán Alonso, Ana Feijoo-Redondo, Gina Abello, et al.. Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea.. Development (Cambridge, England), 2015, 142 (16), pp.2792-800. ⟨hal-01252894⟩

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