For any individual, the residential choice is an arduous task which results from trade-offs between personal wishes, complexity of the housing market and constraints on individual or household. Housing choice is the subject of many researches, but residential choices of persons with physical, mental, sensory, cognitive or intellectual disabilities are rarely studied. Finding adapted housing allowing independent living increases the complexity of the task. More generally, which are the constraints the persons with disabilities have to face for their residential choices? How is the decision made? This communication examines the decision-making process involved in residential choice for persons with disabilities in Lyon (France). Qualitative interviews were conducted with persons with various disabilities, various origins of disability (present from birth or acquired), and various family and employment status. Results show that constraints on residential choice are strong for people with disabilities, whatever their impairment. These often have to face discrimination and inequalities (for example for access to credit and insurance). In addition, lack of social integration can limit access to housing market information. Accessible house can be very expensive while a part of persons with disabilities have low-income, mainly coming from allowance, and trade-offs have to be made between different components of the personal life: personal impairment, income, interpersonal relationships and geographical characteristics. There are specific housing locations preferences for people with disabilities depending on the environment ability to encourage activity or hinder a person's ability to be active. We also show that trade-offs are made between welfare in the house (adapted housing) and locational preferences in the city (accessibility to urban amenities). These preferences and trade-offs can differ depending on the nature of disability. This work is part of a larger project about multiple mobility inequalities, funded via the 'Mobility and Inequalities' research axis of the PST Rhône-Alpes (community of French researchers on the topic of mobility of people and goods).