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Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2016

Copper-Catalyzed Direct C-H Fluoroalkenylation of Heteroarenes

Résumé

Copper-catalyzed direct C–H fluoroalkenylation of heterocycles using various gem-bromofluoroalkenes as electrophiles is reported. This efficient method offers step-economical, low-cost and stereocontrolled access to relevant heteroarylated monofluoroalkenes. The synthesis of fluorinated analogues of biomolecules and therapeutic agents for the treatment of Duchenne muscular dystrophy as application is reported.
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Dates et versions

hal-01251542 , version 1 (06-01-2016)

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Kevin Rousée, Cédric Schneider, J.-P. Bouillon, Vincent Levacher, Christophe Hoarau, et al.. Copper-Catalyzed Direct C-H Fluoroalkenylation of Heteroarenes. Organic & Biomolecular Chemistry, 2016, 14 (1), pp.353-357. ⟨10.1039/C5OB02213D⟩. ⟨hal-01251542⟩
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