Sea level time series derived from TOPEX altimeter and from tide gauge measurements in the Bay of Biscay (Eastern North Atlantic Ocean) are used to investigate the regional sea level rise. Altimetry sea level anomalies are computed from TOPEX measurements and resampled into fixed along track bins in order to obtain consistent records and to approach as close as possible to the coast. Tidal corrections are critical in the estimation of sea level trends; therefore an additional analysis has been carried out in order to identify and correct for residual tidal signals. The obtained mean sea level rise in the region is + 3.09 ± 0.21 mm/year over the period 1993–2002. Tide gauges have been corrected for vertical land motions by means of collocated GPS measurements. GPS-corrected tide gauges and nearby altimetry trends are found to be statistically consistent. The relationship with the atmospheric forcing is also investigated revealing that 15% of this sea level rise is attributed to the atmospheric pressure effects.