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Article Dans Une Revue eMagRes Année : 2015

Conformational Exchange Processes in Biological Systems: Detection by Solid-State NMR

Résumé

We review recent advances in methodologies to study microseconds-to-milliseconds exchange processes in biological molecules using magic-angle spinning solid-state nuclear magnetic resonance (MAS ssNMR) spectroscopy. The particularities of MAS ssNMR, as compared to solution-state NMR, are elucidated using numerical simulations and experimental data. These simulations reveal the potential of MAS NMR to provide detailed insight into short-lived conformations of biological molecules. Recent studies of conformational exchange dynamics in microcrystalline ubiquitin are discussed.
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Dates et versions

hal-01234460 , version 1 (01-12-2015)

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Peixiang Ma, Paul Schanda. Conformational Exchange Processes in Biological Systems: Detection by Solid-State NMR. eMagRes, 2015, ⟨10.1002/9780470034590.emrstm1418⟩. ⟨hal-01234460⟩
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