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Article Dans Une Revue Journal of the American Chemical Society Année : 2015

Nanostructure of materials determined by relayed paramagnetic relaxation enhancement

Résumé

Particle and domain sizes strongly influence the properties of materials. Here we present an NMR approach based on paramagnetic relaxation enhancement (PRE) relayed by spin diffusion (SD), which allows us to determine lengths in the nm pm range. We demonstrate the method on multicomponent organic polymer mixtures by selectively doping one component with a paramagnetic center in order to measure the domain size in a second component. Using this approach we determine domain sizes in ethyl cellulose/hydroxypropyl cellulose film coatings in pharmaceutical controlled release formulations. Here we measure particle sizes ranging from around 50 to 200 nm.

Dates et versions

hal-01229344 , version 1 (16-11-2015)

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Judith Schlagnitweit, Mingxue Tang, Maria Baias, Sara Richardson, Staffan Schantz, et al.. Nanostructure of materials determined by relayed paramagnetic relaxation enhancement. Journal of the American Chemical Society, 2015, 137 (39), pp.12482-12485. ⟨10.1021/jacs.5b08249⟩. ⟨hal-01229344⟩
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