Exploiting the Reactivity of 1,2-Ketoamides: Enantioselective Syn-thesis of Functionalized Pyrrolidines and Pyrrolo-1,4-benzodiaze-pine-2,5-diones
Résumé
A new strategy for the synthesis of optically active pyrrolo[ 1,4]benzo- diazepine-2,5-diones has been developed. The approach is based on an initial Michael addition of functionalized 1,2-ketoamides on nitroalkenes, with a reduction–double cyclization sequence leading to the desired substituted benzodiazepine.
Domaines
Chimie organique
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