ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions - Archive ouverte HAL Access content directly
Journal Articles Nucleic Acids Research Year : 2013

ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions

Abstract

The ESTHER database, which is freely available via a web server (http://bioweb.ensam.inra.fr/esther) and is widely used, is dedicated to proteins with an a/b-hydrolase fold, and it currently contains >30 000 manually curated proteins. Herein, we report those substantial changes towards improvement that we have made to improve ESTHER during the past 8 years since our 2004 update. In particular, we generated 87 new families and increased the coverage of the UniProt Knowledgebase (UniProtKB). We also renewed the ESTHER website and added new visualization tools, such as the Overall Table and the Family Tree. We also address two topics of particular interest to the ESTHER users. First, we explain how the different enzyme classifications (bacterial lipases, peptidases,carboxylesterases) used by different communities of users are combined in ESTHER. Second, we discuss how variations of core architecture or in predicted active site residues result in a more precise clustering of families, and whether this strategy provides trustable hints to identify enzymelike proteins with no catalytic activity.
Fichier principal
Vignette du fichier
2013_Lenfant_NucleicAcidResearch_{3FFA4534-410A-4431-88EC-0E27D68B7F97}.pdf (1.68 Mo) Télécharger le fichier
Origin : Explicit agreement for this submission
Loading...

Dates and versions

hal-01218998 , version 1 (21-10-2015)

Identifiers

Cite

Nicolas Lenfant, Thierry Hotelier, Eric Velluet, Yves Bourne, P. Marchot, et al.. ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions. Nucleic Acids Research, 2013, 41, pp.423-429. ⟨10.1093/nar/gks1154⟩. ⟨hal-01218998⟩
178 View
137 Download

Altmetric

Share

Gmail Facebook X LinkedIn More