Article Dans Une Revue Neuron Année : 2014

Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections.

Résumé

Current neuroimaging techniques have very limited abilities to directly identify and quantify neurotransmitters from brain sections. We have developed a molecular-specific approach for the simultaneous imaging and quantitation of multiple neurotransmitters, precursors, and metabolites, such as tyrosine, tryptamine, tyramine, phenethylamine, dopamine, 3-methoxytyramine, serotonin, GABA, glutamate, acetylcholine, and L-alpha-glycerylphosphorylcholine, in histological tissue sections at high spatial resolutions. The method is employed to directly measure changes in the absolute and relative levels of neurotransmitters in specific brain structures in animal disease models and in response to drug treatments, demonstrating the power of mass spectrometry imaging in neuroscience.
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hal-01215514 , version 1 (14-10-2015)

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  • HAL Id : hal-01215514 , version 1
  • PUBMED : 25453841

Citer

Mohammadreza Shariatgorji, Anders Nilsson, Richard Goodwin, Patrick Källback, Nicoletta Schintu, et al.. Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections.. Neuron, 2014. ⟨hal-01215514⟩

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