Experimental values for the solubility of oxygen in seven fluorinated organic liquids with potential for bio-medical applications—perfluorohexylethane, perfluoromethylcyclohexane, perfluorodimethylcyclohexane, perfluorophenanthrene, perfluorooctane, perfluorodecalin, and perfluorooctylbromide—are reported as a function of temperature and at pressures close to atmospheric. An apparatus based on a saturation method at constant pressure was used to measure solubility at temperatures from 288 to 316 K. The precision of the results, expressed as Ostwald coefficients, is estimated as ±1%. The solubility of oxygen is constant with temperature for perfluorooctylbromide, perfluorodimethylcyclohexane, perfluorohexylethane, perfluorodecalin and perfluorophenanthrene and decreases with temperature for perfluorooctane and perfluoromethylcyclohexane. Some of the experimental results are compared with existing literature values at 298 K.