Suzuki–Miyaura Reactions of Halospirooxindole Derivatives.
Résumé
Starting from 5,5′-dihalo-1′-pentyl-2H-spiro[furo[2,3-b]pyridine-3,3′-indolin]-2′-one, various 5,5′-di(het)aryl-1′-pentyl-2H-spiro[furo[2,3-b]pyridine-3,3′-indolin]-2′-ones were synthesized through palladium-catalysed cross-coupling reactions. A large panel of boronic acids (aryl or heteroaryl) could easily be introduced, leading to a library of new 5- or 5′-monosubstituted and 5,5′-disubstituted 1′-pentyl-2H-spiro[furo[2,3-b]pyridine-3,3′-indolin]-2′-ones.