Comparison of analyses of the XVth QTLMAS common dataset III: Genomic Estimations of Breeding Values - Archive ouverte HAL
Article Dans Une Revue BMC Proceedings Année : 2012

Comparison of analyses of the XVth QTLMAS common dataset III: Genomic Estimations of Breeding Values

Résumé

Background: The QTLMAS XVth dataset consisted of pedigree, marker genotypes and quantitative trait performances of animals with a sib family structure. Pedigree and genotypes concerned 3,000 progenies among those 2,000 were phenotyped. The trait was regulated by 8 QTLs which displayed additive, imprinting or epistatic effects. The 1,000 unphenotyped progenies were considered as candidates to selection and their Genomic Estimated Breeding Values (GEBV) were evaluated by participants of the XVth QTLMAS workshop. This paper aims at comparing the GEBV estimation results obtained by seven participants to the workshop. [br/] Methods: From the known QTL genotypes of each candidate, two "true" genomic values (TV) were estimated by organizers: the genotypic value of the candidate (TGV) and the expectation of its progeny genotypic values (TBV). GEBV were computed by the participants following different statistical methods: random linear models (including BLUP and Ridge Regression), selection variable techniques (LASSO, Elastic Net) and Bayesian methods. Accuracy was evaluated by the correlation between TV (TGV or TBV) and GEBV presented by participants. Rank correlation of the best 10% of individuals and error in predictions were also evaluated. Bias was tested by regression of TV on GEBV. [br/] Results: Large differences between methods were found for all criteria and type of genetic values (TGV, TBV). In general, the criteria ranked consistently methods belonging to the same family. [br/] Conclusions: Bayesian methods - A

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hal-01210357 , version 1 (29-05-2020)

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Pascale Le Roy, Olivier Filangi, Olivier Demeure, Jean Michel Elsen. Comparison of analyses of the XVth QTLMAS common dataset III: Genomic Estimations of Breeding Values. BMC Proceedings, 2012, 6, online (Suppl. 2), Non paginé. ⟨10.1186/1753-6561-6-S2-S3⟩. ⟨hal-01210357⟩
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