2D Correlated MRS as a quantitative method to asses liver fatty acid composition of ob/ob mouse
Résumé
Magnetic Resonance Spectroscopy (MRS) is a well suited method for in vivo characterization of lipid content. However, due to short T2relaxation time and B0 field inhomogeneity, classical methods such as STEAM/PRESS MRS, with clinical or medium preclinical B0 field (B0<9.4T), can be limited by their spectral resolution, leading to quantification ambiguity and thus lipid composition assessment error. The aim of this work is to demonstrate the use of a 2D MRS method called L-COSY and its quantification by a proper dedicated time domain quantification procedure using prior knowledge on triglyceride chemical groups and their connectivity.