Innovative immuno-assay exploiting magnetic nanoparticles and structured micro-magnets
Résumé
Magnetic attraction is widely used in biotechnology, because it provides long-range forces able to capture molecules of interest.
Micro-magnet arrays from Néel Institute (CNRS, Grenoble, FRANCE) can efficiently trap highly diffusive magnetic nanoparticles thanks
to their high local gradients. This innovative technology is used to develop fast immuno-assays that take advantage of a radical size
reduction, compared to commercial technology.
Our first objective is to embed micro-magnets in 96 wells plates to accelerate and enhance performances of standard ELISA.
As micro-magnets are embedded in standard microwell plates, our plates remain fully compatible with plates readers. We will
compare the ELISA performances applied to ovalbumin antibody detection.