A thermostable transketolase evolved for aliphatic aldehyde acceptors. - Archive ouverte HAL
Article Dans Une Revue Chemical Communications Année : 2015

A thermostable transketolase evolved for aliphatic aldehyde acceptors.

Résumé

Directed evolution of the thermostable transketolase from Geobacillus stearothermophilus based on a pH-based colorimetric screening of smart libraries yielded several mutants with up to 16-fold higher activity for aliphatic aldehydes and high enantioselectivity (>95% ee) in the asymmetric carboligation step.

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Chimie

Stéphanie Bonnefoy  : Connectez-vous pour contacter le contributeur

https://hal.science/hal-01207844

Soumis le : jeudi 1 octobre 2015-14:21:43

Dernière modification le : mardi 22 octobre 2024-13:34:16

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Dates et versions

hal-01207844 , version 1 (01-10-2015)

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Citer

Dong Yi, Thangavelu Saravanan, Titu Devamani, Franck Charmantray, Laurence Hecquet, et al.. A thermostable transketolase evolved for aliphatic aldehyde acceptors.. Chemical Communications, 2015, 51, pp.480-483. ⟨10.1039/C4CC08436E⟩. ⟨hal-01207844⟩

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