Straightforward Synthesis of Terminally Phosphorylated L-Sugars via Multienzymatic Cascade Reactions. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Advanced Synthesis and Catalysis Année : 2015

Straightforward Synthesis of Terminally Phosphorylated L-Sugars via Multienzymatic Cascade Reactions.

Résumé

Two kinases and the key fructose-6-phosphate aldolase (FSA) were involved in a one-pot multienzymatic procedure to obtain rare L-sugars. Starting from simple achiral substrates such as glycolaldehyde and formaldehyde, L-glyceraldehyde-3-phosphate (L-G3P) was generated. When this latter compound was used as an FSA acceptor substrate along with four different donor compounds, four terminally phosphorylated L-monosaccharides from C5 to C7 chain lengths were prepared in good isolated yields.

Dates et versions

hal-01206488 , version 1 (29-09-2015)

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Citer

Virgil Hélaine, Rima Mahdi, G. V. Sudhir babu, Véronique de Berardinis, Roland Wohlgemuth, et al.. Straightforward Synthesis of Terminally Phosphorylated L-Sugars via Multienzymatic Cascade Reactions.. Advanced Synthesis and Catalysis, 2015, 357, pp.1703-1708. ⟨10.1002/adsc.201500190⟩. ⟨hal-01206488⟩
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