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                <term xml:lang="en">probiotique</term>
                <term xml:lang="en">acide gras volatil</term>
                <term xml:lang="en">cobalamine</term>
                <term xml:lang="en">lait fermenté</term>
                <term xml:lang="en">cancer gastrique</term>
                <term xml:lang="en">bactérie propionique</term>
                <term xml:lang="en">acide folique</term>
                <term xml:lang="en">apoptose</term>
                <term xml:lang="en">chimiothérapie</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv.ida">Life Sciences [q-bio]/Food engineering</classCode>
              <classCode scheme="halDomain" n="sdv.aen">Life Sciences [q-bio]/Food and Nutrition</classCode>
              <classCode scheme="halDomain" n="sdv.mhep">Life Sciences [q-bio]/Human health and pathology</classCode>
              <classCode scheme="vocinrae-old" n="intestin">intestin</classCode>
              <classCode scheme="vocinrae-old" n="lait fermenté">lait fermenté</classCode>
              <classCode scheme="vocinrae-old" n="probiotique">probiotique</classCode>
              <classCode scheme="vocinrae-old" n="propionibacterium freudenreichii">propionibacterium freudenreichii</classCode>
              <classCode scheme="vocinrae-old" n="santé humaine">santé humaine</classCode>
              <classCode scheme="vocinrae-old" n="bactérie probiotique">bactérie probiotique</classCode>
              <classCode scheme="vocinrae-old" n="prévention des maladies">prévention des maladies</classCode>
              <classCode scheme="vocinrae-old" n="acide folique">acide folique</classCode>
              <classCode scheme="vocinrae-old" n="acide gras volatil">acide gras volatil</classCode>
              <classCode scheme="vocinrae-old" n="apoptose">apoptose</classCode>
              <classCode scheme="vocinrae-old" n="cancer du colon">cancer du colon</classCode>
              <classCode scheme="vocinrae-old" n="estomac">estomac</classCode>
              <classCode scheme="vocinrae-old" n="relation alimentation santé">relation alimentation santé</classCode>
              <classCode scheme="vocinrae-old" n="cancer">cancer</classCode>
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              <p>Food-grade dairy propionibacteria release beneficial short chain fatty acids (SCFAs), folic acid and cobalamin. They induce apoptosis via the mitochondrial death pathway. We investigated their synergy with drugs used in gastric and colorectal cancer. Fermented milk containing propionibacteria and SCFAS acetate and propionate, as well as its cell-free supernatant, induced apoptosis in gastric HGT-1 and colic HT-29. Characterization of cells revealed apoptosis induction evidenced by chromatin condensation, DNA laddering, emergence of a subG1 population, phosphatidylserine exposure at the plasma membrane outer leaflet and cytochrome c release. Interestingly, the fermented milk was shown to potentiate the cytotoxic effect of molecules used in cancer chemotherapy, camptothecin and TRAIL (TNF Related Apoptosis Inducing Ligand). These results open new perspectives in the field of colon cancer cells prevention and/or treatment. Such a fermented product, or the propionibacterium alone, may be proposed as a food supplement to enhance the effects of anticancer treatments.</p>
            </abstract>
            <abstract xml:lang="fr">
              <p>Les bactéries propioniques laitières produisent des acides gras volatils (AGV), acide folique et cobalamine, composés bénéfiques. Elles induisent l’apoptose via la voie mitochondriale. Nous avons recherché leur synergie avec des drogues utilisées dans le cancer gastrique ou colique. Un lait fermenté contenant des bactéries propioniques et les AGVs propionate et acétate a induit l’apoptose de cellules gastriques HGT-1 et coliques HT-29. L’étude des cellules a révélé l’induction de l’apoptose : condensation de la chromatine, fragmentation de l’ADN, l’émergence d’une population subG1, l’externalisation des phosphatidylserines et le relargage du cytochrome c. De manière intéressante, le lait fermenté a potentialisé les effets cytotoxiques de molécules utilisées en chimiothérapie, camptothécine et TRAIL (TNF Related Apoptosis Inducing Ligand). Ces résultats ouvrent de nouvelles perspectives dans le domaine du traitement ou de la prévention des cancers digestifs. Un tel produit fermenté, ou les propionibactéries seules, pourrait être proposé comme supplément alimentaire pour augmenter l’efficacité de traitements anti-cancéreux.</p>
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