Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cancer Cell Année : 2010

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.

Houtan Noushmehr
Heidi Phillips
  • Fonction : Auteur
Kanan Pujara
  • Fonction : Auteur
Fei Pan

Résumé

We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator phenotype (G-CIMP). We validated G-CIMP in a set of non-TCGA glioblastomas and low-grade gliomas. G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations. Patients with G-CIMP tumors are younger at the time of diagnosis and experience significantly improved outcome. These findings identify G-CIMP as a distinct subset of human gliomas on molecular and clinical grounds.

Dates et versions

hal-01201573 , version 1 (17-09-2015)

Identifiants

Citer

Houtan Noushmehr, Daniel Weisenberger, Kristin Diefes, Heidi Phillips, Kanan Pujara, et al.. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.. Cancer Cell, 2010, 17 (5), pp.510-22. ⟨10.1016/j.ccr.2010.03.017⟩. ⟨hal-01201573⟩
295 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More