Common genetic variants influence human subcortical brain structures.
Derrek P Hibar
(1)
,
Jason L Stein
(1)
,
Miguel E Renteria
(2)
,
Alejandro Arias-Vasquez
(3, 4)
,
Sylvane Desrivières
(5)
,
Neda Jahanshad
(1)
,
Roberto Toro
(6, 7, 8)
,
Katharina Wittfeld
(9, 10)
,
Lucija Abramovic
(11)
,
Micael Andersson
(12)
,
Benjamin S Aribisala
(13, 14)
,
Nicola J Armstrong
(15)
,
Manon Bernard
(16)
,
Marc M Bohlken
(11)
,
Marco P Boks
(11)
,
Janita Bralten
(17, 18)
,
Andrew A Brown
(19)
,
M Mallar Chakravarty
(20)
,
Qiang Chen
(21)
,
Christopher R K Ching
(22)
,
Gabriel Cuellar-Partida
(2)
,
Anouk den Braber
(23)
,
Sudheer Giddaluru
(19, 24)
,
Aaron L Goldman
(25)
,
Oliver Grimm
(26)
,
Tulio Guadalupe
(27, 28)
,
Johanna Hass
(29)
,
Girma Woldehawariat
(30)
,
Avram J Holmes
(31, 32)
,
Martine Hoogman
(33)
,
Deborah Janowitz
(10)
,
Tianye Jia
(34)
,
Sungeun Kim
(35, 36)
,
Marieke Klein
,
Bernd Kraemer
(37)
,
Phil H Lee
(38)
,
Loes M Olde Loohuis
(39)
,
Michelle Luciano
(40)
,
Christine Macare
(5)
,
Karen A Mather
(41)
,
Manuel Mattheisen
(42, 43, 44)
,
Yuri Milaneschi
(45)
,
Kwangsik Nho
(35, 36)
,
Martina Papmeyer
(13)
,
Adaikalavan Ramasamy
(46)
,
Shannon L Risacher
(35, 36)
,
Roberto Roiz-Santiañez
(47)
,
Emma J Rose
(48)
,
Alireza Salami
(49, 50)
,
Philipp G Sämann
(51)
,
Lianne Schmaal
(45)
,
Andrew J Schork
(52, 53)
,
Jean Shin
(54)
,
Lachlan T Strike
(55, 56, 57)
,
Alexander Teumer
(58)
,
Marjolein M J van Donkelaar
(17, 18)
,
Kristel R van Eijk
(11)
,
Raymond K Walters
(59)
,
Lars T Westlye
(19, 60)
,
Christopher D Whelan
(1)
,
Anderson M Winkler
(61)
,
Marcel P Zwiers
(18)
,
Saud Alhusaini
(62, 63)
,
Lavinia Athanasiu
(19)
,
Stefan Ehrlich
(64)
,
Marina M H Hakobjan
(17, 18)
,
Cecilie B Hartberg
(19, 65)
,
Unn K Haukvik
(19)
,
Angelien J G a M Heister
(17, 18)
,
David Hoehn
(51)
,
Dalia Kasperaviciute
(66, 67)
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David C M Liewald
(13)
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Lorna M Lopez
(13)
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Remco R R Makkinje
(17, 18)
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Mar Matarin
(68)
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Marlies a M Naber
(17, 18)
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D Reese Mckay
(69, 70)
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Margaret Needham
(71)
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Allison C Nugent
(72)
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Benno Pütz
(73)
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Natalie A Royle
(13)
,
Li Shen
(74)
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Emma Sprooten
(13, 69, 70)
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Daniah Trabzuni
(75, 76)
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Saskia S L van Der Marel
(17, 18)
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Kimm J E van Hulzen
(17, 18)
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Esther Walton
(77)
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Christiane Wolf
(78, 79)
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Laura Almasy
(80)
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David Ames
(81)
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Sampath Arepalli
(82)
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Amelia A Assareh
(83)
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Mark E Bastin
(13)
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Henry Brodaty
(84, 85)
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Kazima B Bulayeva
(86)
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Melanie A Carless
(87)
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Sven Cichon
(42, 43, 88, 89)
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Aiden Corvin
(90, 91)
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Joanne E Curran
(92)
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Michael Czisch
(93)
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Greig I de Zubicaray
(94)
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Allissa Dillman
(95)
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Ravi Duggirala
(87)
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Thomas D Dyer
(87, 96)
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Susanne Erk
(97)
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Iryna O Fedko
(23)
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Luigi Ferrucci
(30)
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Tatiana M Foroud
(98)
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Peter T Fox
(96, 99)
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Masaki Fukunaga
(100)
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J Raphael Gibbs
(75, 101)
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Harald H H Göring
(102)
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Robert C Green
(103)
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Sebastian Guelfi
(75)
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Narelle K Hansell
(40)
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Catharina A Hartman
(40)
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Katrin Hegenscheid
(10)
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Andreas Heinz
(104)
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Dena G Hernandez
(105)
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Dirk J Heslenfeld
(10)
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Pieter J Hoekstra
(106)
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Florian Holsboer
(107)
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Georg Homuth
(108)
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Jouke-Jan Hottenga
(58)
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Masashi Ikeda
(109)
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Clifford R Jack
(110)
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Mark Jenkinson
(111)
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Robert Johnson
(112)
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Ryota Kanai
(113, 114)
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Maria Keil
(37)
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Jack W Kent
(115)
,
Peter Kochunov
(116)
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John B Kwok
(117)
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Stephen M Lawrie
(13)
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Xinmin Liu
(30, 118)
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Dan L Longo
(119)
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Katie L Mcmahon
(120)
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Eva Meisenzahl
(121)
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Ingrid Melle
(122, 123, 124, 125)
,
Sebastian Mohnke
(126)
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Grant W Montgomery
(127, 55)
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Jeanette C Mostert
(17, 18)
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Thomas W Mühleisen
(42, 43)
,
Michael A Nalls
(30)
,
Thomas E Nichols
(128)
,
Lars G Nilsson
(49)
,
Markus M Nöthen
(42, 43)
,
Kazutaka Ohi
(129)
,
Rene L Olvera
(130)
,
Rocio Perez-Iglesias
(47, 131)
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G Bruce Pike
(132, 133)
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Steven G Potkin
(134)
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Ivar Reinvang
(60)
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Simone Reppermund
(84)
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Marcella Rietschel
(135, 136)
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Nina Romanczuk-Seiferth
(126)
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Glenn D Rosen
(137)
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Dan Rujescu
(138)
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Knut Schnell
(139)
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Peter R Schofield
(140)
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Colin Smith
(141)
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Vidar M Steen
(19, 24)
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Jessika E Sussmann
(13)
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Anbupalam Thalamuthu
(142)
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Arthur W Toga
(143)
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Bryan J Traynor
(95)
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Juan Troncoso
(144)
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Jessica A Turner
(145)
,
Maria C Valdés Hernández
(13)
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Dennis van 'T Ent
(23)
,
Marcel van Der Brug
(146)
,
Nic J A van Der Wee
(147)
,
Marie-Jose van Tol
(148)
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Dick J Veltman
(45)
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Thomas H Wassink
(149)
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Eric Westman
(150)
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Ronald H Zielke
(112)
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Alan B Zonderman
(30)
,
David G Ashbrook
(151)
,
Reinmar Hager
(151)
,
Lu Lu
(152, 153)
,
Francis J Mcmahon
,
Derek W Morris
(90, 91)
,
Robert W Williams
(154)
,
Han G Brunner
(155)
,
Randy L Buckner
(156)
,
Jan K Buitelaar
(157)
,
Wiepke Cahn
(158)
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Vince D Calhoun
(159, 160)
,
Gianpiero L Cavalleri
(161)
,
Benedicto Crespo-Facorro
(47)
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Anders M Dale
(162)
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Gareth E Davies
(163)
,
Norman Delanty
(63, 164)
,
Chantal Depondt
(165)
,
Srdjan Djurovic
(122, 166)
,
Wayne C Drevets
(167)
,
Thomas Espeseth
(19, 60)
,
Randy L Gollub
(168)
,
Beng-Choon Ho
(169)
,
Wolfgang Hoffmann
(170)
,
Norbert Hosten
(10)
,
René S Kahn
,
Stephanie Le Hellard
(19, 24)
,
Andreas Meyer-Lindenberg
(26)
,
Bertram Müller-Myhsok
(171)
,
Matthias Nauck
(172)
,
Lars Nyberg
(173)
,
Massimo Pandolfo
(165)
,
Brenda W J H Penninx
(127)
,
Joshua L Roffman
(32)
,
Sanjay M Sisodiya
(68)
,
Jordan W Smoller
(174, 175)
,
Hans van Bokhoven
(176)
,
Neeltje E M van Haren
(11)
,
Henry Völzke
(177)
,
Henrik Walter
(178)
,
Michael W Weiner
(179)
,
Wei Wen
(180)
,
Tonya White
(181, 182)
,
Ingrid Agartz
(122)
,
Ole A Andreassen
(122, 123)
,
John Blangero
(87, 96)
,
Dorret I Boomsma
(58)
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Rachel M Brouwer
(183)
,
Dara M Cannon
(167)
,
Mark R Cookson
(184)
,
Eco J C de Geus
(40)
,
Ian J Deary
(185)
,
Gary Donohoe
(90, 167)
,
Guillén Fernández
(186, 187)
,
Simon E Fisher
(18, 27)
,
Clyde Francks
(18, 27)
,
David C Glahn
(69, 70)
,
Hans J Grabe
(188)
,
Oliver Gruber
(189)
,
John Hardy
(75)
,
Ryota Hashimoto
(190)
,
Hilleke E Hulshoff Pol
(11)
,
Erik G Jönsson
(191, 192)
,
Iwona Kloszewska
(193)
,
Simon Lovestone
(194)
,
Venkata S Mattay
(195)
,
Patrizia Mecocci
(196)
,
Colm Mcdonald
(197)
,
Andrew M Mcintosh
(198)
,
Roel A Ophoff
(199)
,
Tomas Paus
(200, 201)
,
Zdenka Pausova
(202)
,
Mina Ryten
(75, 203)
,
Perminder S Sachdev
(41, 180)
,
Andrew J Saykin
(35, 36, 126)
,
Andy Simmons
(204)
,
Andrew Singleton
(82)
,
Hilkka Soininen
(205)
,
Joanna M Wardlaw
(13)
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Michael E Weale
(206)
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Daniel R Weinberger
(207, 208)
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Hieab H H Adams
(209)
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Lenore J Launer
(18)
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Stephan Seiler
(210)
,
Reinhold Schmidt
(211)
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Ganesh Chauhan
(212)
,
Claudia L Satizabal
(213)
,
James T Becker
(214)
,
Lisa Yanek
(215)
,
Sven J van Der Lee
(216)
,
Maritza Ebling
(168, 217)
,
Bruce Fischl
(218, 168)
,
W T Longstreth
(219)
,
Douglas Greve
(168, 217)
,
Helena Schmidt
(220)
,
Paul Nyquist
(221)
,
Louis N Vinke
(168, 217)
,
Cornelia M van Duijn
(222, 223, 216)
,
Luting Xue
(224)
,
Bernard Mazoyer
(225)
,
Joshua C Bis
(219)
,
Vilmundur Gudnason
(226, 227)
,
Sudha Seshadri
(228)
,
M Arfan Ikram
(223, 216)
,
Nicholas G Martin
(229)
,
Margaret J Wright
(2, 230)
,
Gunter Schumann
(5)
,
Barbara Franke
(17, 18)
,
Paul M Thompson
(1)
,
Sarah E Medland
(231, 55)
1
David Geffen School of Medicine [Los Angeles]
2 QIMR Berghofer Medical Research Institute
3 Department of Psychiatry
4 Department of Human Genetics
5 Institute of Psychiatry, Psychology & Neuroscience, King's College London
6 PRES Sorbonne Paris Cité
7 GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions
8 CNRS - UMR3571 - Gènes, Synapses et Cognition
9 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
10 Greifswald University Hospital
11 University Medical Center [Utrecht]
12 European Commission
13 University of Edinburgh
14 LASU - Lagos State University
15 HWU - Heriot-Watt University [Edinburgh]
16 Unité d'expérimentation sur les Ruminants de Theix
17 Radboud University Medical Center [Nijmegen]
18 Donders Institute for Brain, Cognition and Behaviour
19 UiO - University of Oslo
20 Montreal Neurological Institute and Hospital
21 School of Technical Physics
22 Dept. of Mechanical Engineering
23 Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam 1081 BT, The Netherlands
24 Haukeland University Hospital
25 PC2A - Physicochimie des Processus de Combustion et de l’Atmosphère - UMR 8522
26 Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim
27 Language and Genetics Department [Nijmegen]
28 IMPRS - International Max Planck Research School for Language Sciences
29 Georgia Institute of Technology [Atlanta]
30 NIH - National Institutes of Health [Bethesda]
31 Yale University [New Haven]
32 Department of Psychiatry
33 Mental Health Sciences Unit
34 BNU - Beijing Normal University
35 Indiana University School of Medicine
36 Indiana Alzheimer Disease Center
37 Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen 37075, Germany
38 Scottish Fish Immunology Research Centre, School of Biological Sciences
39 UCLA - University of California [Los Angeles]
40 Medstar Research Institute
41 Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
42 Department of Genomics, Life and Brain Center
43 Institute of Human Genetics
44 Department of Biomedicine and the Centre for Integrative Sequencing
45 Department of Psychiatry
46 Respiratory Epidemiology and Public Health
47 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
48 IPCM - Institut Parisien de Chimie Moléculaire
49 Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå 901 87, Sweden
50 ARC - Aging Research Center [Karolinska Institutet]
51 Max Planck Institute of Psychiatry
52 Neuro - UC San Diego - Department of Neurosciences [Univ California San Diego]
53 CogSci - UC San Diego - Department of Cognitive Sciences [Univ California San Diego]
54 SickKids - The Hospital for sick children [Toronto]
55 Queensland Institute of Medical Research
56 School of Psychology, University of Queensland, Brisbane 4072, Australia
57 Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia
58 King‘s College London
59 Department of Genomics of Common Disease
60 Department of Psychology [Oslo]
61 Deutsche Bundesbank
62 Department of Neurology and Neurosurgery [Montreal]
63 Molecular and Cellular Therapeutics
64 MetaGenoPolis
65 Department of Psychiatric Research and Development, Diakonhjemmet Hospital, Oslo 0319, Norway
66 UCL Institute of Neurology and Epilepsy Society
67 Department of Medicine
68 Clinical And Experimental Epilepsy
69 Dpt of Psychiatry [New Haven]
70 Hartford Hospital
71 Neuropsychiatric Genetics Research Group and Department of Psychiatry, Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
72 Institute of Food & Health, University College Dublin,
73 Statistical Genetics Group
74 State Key Laboratory of Lead Compound Research
75 Reta Lila Weston Institute and Department of Molecular Neuroscience
76 Department of Genetics
77 EDC (UMR_7216) - Centre épigénétique et destin cellulaire
78 Dundee Technopole
79 Ninewells Hospital and Medical School, Biomedical Research Centre
80 Department of Genetics
81 Department of Psychiatry and National Ageing Research Institute
82 Department of Clinical Genetics
83 Department of Medical Parasitology and Mycology
84 Centre for Healthy Brain Ageing
85 Dementia Collaborative Research Centre
86 N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia
87 Texas Biomedical Research Institute [San Antonio, TX]
88 INM-1 - Institute of Neuroscience and Medicine
89 Division of Medical Genetics
90 Department of Psychiatry
91 Neuropsychiatric Genetics Research Group
92 Department of Materials Science & Metallurgy
93 Bijvoet Center of Biomolecular Research [Utrecht]
94 School of Psychology, University of Queensland
95 Laboratory of Neurogenetics
96 UTHealth - The University of Texas Health Science Center at Houston
97 Department of Genomics
98 Department of Medical and Molecular Genetics
99 South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
100 Biofunctional Imaging, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
101 University of Melbourne
102 Public Health Genomics Unit
103 Department of Biomolecular Engineering
104 Rheinische Friedrich-Wilhelms-Universität Bonn
105 Estación Experimental de Pastos y Forrajes “Indio Hatuey”
106 Department of Psychiatry
107 Neuronal Plasticity / Mouse Behaviour
108 Interfaculty Institute for Genetics and Functional Genomics
109 Department of Psychiatry, Fujita Health University School of Medicine, Toyoake 470-1192, Japan
110 Department of Radiology
111 Department of Clinical Neurology [Oxford]
112 University of Maryland School of Medicine
113 School of Psychology, University of Sussex, Brighton BN1 9QH, UK
114 Institute of Cognitive Neuroscience
115 United Kingdom Met Office [Exeter]
116 Department of Psychiatry
117 Department of Civil and Structural Engineering
118 CUIMC - Columbia University Irving Medical Center
119 Lymphocyte Cell Biology Unit, Laboratory of Genetics
120 Centre for Advanced Imaging
121 Psychiatry and Psychotherapy
122 KG Jebsen Centre for Psychosis Research
123 Division of Mental Health and Addiction
124 Institute of Clinical Medicine [Oslo]
125 Division of Mental Health and Addiction
126 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
127 Genetic Epidemiology Unit
128 Department of Statistics [Warwick]
129 Department of Psychiatry
130 Department of Medical and Molecular Genetics
131 Institute of Psychiatry, King’s College London, London SE5 8AF, UK
132 Department of Neurology [University of Calgary]
133 Department of Clinical Neuroscience [University of Calgary]
134 Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA
135 Department of Genetic Epidemiology in Psychiatry
136 Department of Psychiatry
137 Space and Naval Warfare Systems Center
138 Klinik für Psychiatrie
139 Department of Psychiatry, Division of Medical Psychology
140 Genetics of Mental Illness and Brain Function
141 UMR DAP - Développement et amélioration des plantes
142 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia
143 LONI - Laboratory of Neuro Imaging [Los Angeles]
144 Departamento de Física Aplicada
145 Georgia State University
146 Genentech, Inc. [San Francisco]
147 Psychiatry and Leiden Institute for Brain and Cognition
148 Leiden University Medical Center (LUMC)
149 Department of Psychiatry
150 Department of Neurobiology, Care Sciences and Society
151 University of Manchester [Manchester]
152 UTHSC - The University of Tennessee Health Science Center [Memphis]
153 iangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong 226001, China
154 CUDOS - Centre for Ultrahigh Bandwidth Devices for Optical Systems
155 Department of Human Genetics
156 Cognitive Neuroscience Laboratory (CNL)
157 Donders Center for Cognitive Neuroimaging
158 Department of Psychiatry
159 The Mind Research Network
160 ECE Department - Department of Electrical and Computer Engineering [Albuquerque]
161 Division of Molecular and Cellular Therapeutics
162 SAMS - Scottish Association for Marine Science
163 Structural Biology Laboratory, Department of Chemistry, University of York
164 Neurology Division, Beaumont Hospital, Dublin 9, Ireland
165 Department of Neurology
166 Deparment of Medical Genetics
167 Human Genetics Branch
168 Athinoula A. Martinos Center for Biomedical Imaging
169 Department of Psychiatry, University of Iowa
170 Institute for Community Medicine, Department Epidemiology of Health Care and Community Health
171 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy
172 Institute of Clinical Chemistry and Laboratory Medicine
173 Department of Health Science, Division of Health and Rehabilitation
174 Stanley Center for Psychiatric Research
175 Psychiatric and Neurodevelopmental Genetics Unit
176 849 Department of Human Genetics
177 Institute for Community Medicine
178 Institute for Energy Systems and Thermodynamics
179 Renyi Institute
180 Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW
181 Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre, Rotterdam 3000 CB, The Netherlands
182 Department of Radiology, Erasmus University Medical Centre, Rotterdam 3015 CN, The Netherlands
183 VU - Vrije Universiteit Amsterdam [Amsterdam]
184 Cell Biology and Gene Expression Section
185 Dept of Psychology
186 Laboratoire de Recherche Magellan
187 ISEOR - Institut de Socio-économie des Entreprises et des ORganisations
188 Department of Psychiatry and Psychotherapy
189 LIG - Laboratoire d'Informatique de Grenoble
190 Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development,
191 Centre for Allergy Research
192 Department of Medicine, Clinical Pharmacology Unit
193 MUL - Medical University of Łódź
194 Psychiatry Institute
195 Department of Health and Human Services
196 Institute of Gerontology and Geriatrics
197 CSIRO - Commonwealth Scientific and Industrial Research Organisation [Canberra]
198 Australian Centre for Research into Injury in Sport and its Prevention
199 Department of Psychiatry
200 School of Psychology [Nottingham]
201 MNI - McConnell Brain Imaging Centre
202 SickKids - The Hospital for sick children
203 Department of Medical and Molecular Genetics
204 ECMWF - European Centre for Medium-Range Weather Forecasts
205 Department of neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
206 Centre for Population Health Sciences
207 LIBD - Lieber Institute for Brain Development [Baltimore]
208 JHU - Johns Hopkins University
209 Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique
210 Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz 8010, Austria
211 AIT - Austrian Institute of Technology [Vienna]
212 INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France
213 INSERM, Neuroepidemiology U708, Bordeaux, France
214 KIT - Karlsruhe Institute of Technology
215 General Internal Medicine, Johns Hopkins School of Medicine
216 Erasmus MC - Erasmus University Medical Center [Rotterdam]
217 HMS - Harvard Medical School [Boston]
218 CSAIL - Computer Science and Artificial Intelligence Laboratory [Cambridge]
219 University of Washington [Seattle]
220 Department of Physics [Stockholm]
221 Department of Neurology
222 Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands
223 Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
224 BU - Boston University [Boston]
225 GIN - UMR 5296 - Groupe d'Imagerie Neurofonctionnelle
226 Faculty of Medicine
227 Icelandic Heart Association, Kopavogur, Iceland.
228 BUSM - Boston University School of Medicine
229 LIMATB - Laboratoire d'Ingénierie des Matériaux de Bretagne
230 School of Psychology, University of Queensland, Brisbane 4072, Australia
231 BROAD INSTITUTE - Broad Institute of MIT and Harvard
2 QIMR Berghofer Medical Research Institute
3 Department of Psychiatry
4 Department of Human Genetics
5 Institute of Psychiatry, Psychology & Neuroscience, King's College London
6 PRES Sorbonne Paris Cité
7 GHFC (UMR_3571 / U-Pasteur_1) - Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions
8 CNRS - UMR3571 - Gènes, Synapses et Cognition
9 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
10 Greifswald University Hospital
11 University Medical Center [Utrecht]
12 European Commission
13 University of Edinburgh
14 LASU - Lagos State University
15 HWU - Heriot-Watt University [Edinburgh]
16 Unité d'expérimentation sur les Ruminants de Theix
17 Radboud University Medical Center [Nijmegen]
18 Donders Institute for Brain, Cognition and Behaviour
19 UiO - University of Oslo
20 Montreal Neurological Institute and Hospital
21 School of Technical Physics
22 Dept. of Mechanical Engineering
23 Biological Psychology, Neuroscience Campus Amsterdam & EMGO Institute for Health and Care Research, VU University & VU Medical Center, Amsterdam 1081 BT, The Netherlands
24 Haukeland University Hospital
25 PC2A - Physicochimie des Processus de Combustion et de l’Atmosphère - UMR 8522
26 Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim
27 Language and Genetics Department [Nijmegen]
28 IMPRS - International Max Planck Research School for Language Sciences
29 Georgia Institute of Technology [Atlanta]
30 NIH - National Institutes of Health [Bethesda]
31 Yale University [New Haven]
32 Department of Psychiatry
33 Mental Health Sciences Unit
34 BNU - Beijing Normal University
35 Indiana University School of Medicine
36 Indiana Alzheimer Disease Center
37 Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen 37075, Germany
38 Scottish Fish Immunology Research Centre, School of Biological Sciences
39 UCLA - University of California [Los Angeles]
40 Medstar Research Institute
41 Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia
42 Department of Genomics, Life and Brain Center
43 Institute of Human Genetics
44 Department of Biomedicine and the Centre for Integrative Sequencing
45 Department of Psychiatry
46 Respiratory Epidemiology and Public Health
47 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
48 IPCM - Institut Parisien de Chimie Moléculaire
49 Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå 901 87, Sweden
50 ARC - Aging Research Center [Karolinska Institutet]
51 Max Planck Institute of Psychiatry
52 Neuro - UC San Diego - Department of Neurosciences [Univ California San Diego]
53 CogSci - UC San Diego - Department of Cognitive Sciences [Univ California San Diego]
54 SickKids - The Hospital for sick children [Toronto]
55 Queensland Institute of Medical Research
56 School of Psychology, University of Queensland, Brisbane 4072, Australia
57 Centre for Advanced Imaging, University of Queensland, Brisbane 4072, Australia
58 King‘s College London
59 Department of Genomics of Common Disease
60 Department of Psychology [Oslo]
61 Deutsche Bundesbank
62 Department of Neurology and Neurosurgery [Montreal]
63 Molecular and Cellular Therapeutics
64 MetaGenoPolis
65 Department of Psychiatric Research and Development, Diakonhjemmet Hospital, Oslo 0319, Norway
66 UCL Institute of Neurology and Epilepsy Society
67 Department of Medicine
68 Clinical And Experimental Epilepsy
69 Dpt of Psychiatry [New Haven]
70 Hartford Hospital
71 Neuropsychiatric Genetics Research Group and Department of Psychiatry, Trinity College Institute of Psychiatry, Trinity College Dublin, Dublin 2, Ireland
72 Institute of Food & Health, University College Dublin,
73 Statistical Genetics Group
74 State Key Laboratory of Lead Compound Research
75 Reta Lila Weston Institute and Department of Molecular Neuroscience
76 Department of Genetics
77 EDC (UMR_7216) - Centre épigénétique et destin cellulaire
78 Dundee Technopole
79 Ninewells Hospital and Medical School, Biomedical Research Centre
80 Department of Genetics
81 Department of Psychiatry and National Ageing Research Institute
82 Department of Clinical Genetics
83 Department of Medical Parasitology and Mycology
84 Centre for Healthy Brain Ageing
85 Dementia Collaborative Research Centre
86 N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow 119333, Russia
87 Texas Biomedical Research Institute [San Antonio, TX]
88 INM-1 - Institute of Neuroscience and Medicine
89 Division of Medical Genetics
90 Department of Psychiatry
91 Neuropsychiatric Genetics Research Group
92 Department of Materials Science & Metallurgy
93 Bijvoet Center of Biomolecular Research [Utrecht]
94 School of Psychology, University of Queensland
95 Laboratory of Neurogenetics
96 UTHealth - The University of Texas Health Science Center at Houston
97 Department of Genomics
98 Department of Medical and Molecular Genetics
99 South Texas Veterans Health Care System, San Antonio, Texas 78229, USA
100 Biofunctional Imaging, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
101 University of Melbourne
102 Public Health Genomics Unit
103 Department of Biomolecular Engineering
104 Rheinische Friedrich-Wilhelms-Universität Bonn
105 Estación Experimental de Pastos y Forrajes “Indio Hatuey”
106 Department of Psychiatry
107 Neuronal Plasticity / Mouse Behaviour
108 Interfaculty Institute for Genetics and Functional Genomics
109 Department of Psychiatry, Fujita Health University School of Medicine, Toyoake 470-1192, Japan
110 Department of Radiology
111 Department of Clinical Neurology [Oxford]
112 University of Maryland School of Medicine
113 School of Psychology, University of Sussex, Brighton BN1 9QH, UK
114 Institute of Cognitive Neuroscience
115 United Kingdom Met Office [Exeter]
116 Department of Psychiatry
117 Department of Civil and Structural Engineering
118 CUIMC - Columbia University Irving Medical Center
119 Lymphocyte Cell Biology Unit, Laboratory of Genetics
120 Centre for Advanced Imaging
121 Psychiatry and Psychotherapy
122 KG Jebsen Centre for Psychosis Research
123 Division of Mental Health and Addiction
124 Institute of Clinical Medicine [Oslo]
125 Division of Mental Health and Addiction
126 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
127 Genetic Epidemiology Unit
128 Department of Statistics [Warwick]
129 Department of Psychiatry
130 Department of Medical and Molecular Genetics
131 Institute of Psychiatry, King’s College London, London SE5 8AF, UK
132 Department of Neurology [University of Calgary]
133 Department of Clinical Neuroscience [University of Calgary]
134 Psychiatry and Human Behavior, University of California, Irvine, California 92617, USA
135 Department of Genetic Epidemiology in Psychiatry
136 Department of Psychiatry
137 Space and Naval Warfare Systems Center
138 Klinik für Psychiatrie
139 Department of Psychiatry, Division of Medical Psychology
140 Genetics of Mental Illness and Brain Function
141 UMR DAP - Développement et amélioration des plantes
142 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia
143 LONI - Laboratory of Neuro Imaging [Los Angeles]
144 Departamento de Física Aplicada
145 Georgia State University
146 Genentech, Inc. [San Francisco]
147 Psychiatry and Leiden Institute for Brain and Cognition
148 Leiden University Medical Center (LUMC)
149 Department of Psychiatry
150 Department of Neurobiology, Care Sciences and Society
151 University of Manchester [Manchester]
152 UTHSC - The University of Tennessee Health Science Center [Memphis]
153 iangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong 226001, China
154 CUDOS - Centre for Ultrahigh Bandwidth Devices for Optical Systems
155 Department of Human Genetics
156 Cognitive Neuroscience Laboratory (CNL)
157 Donders Center for Cognitive Neuroimaging
158 Department of Psychiatry
159 The Mind Research Network
160 ECE Department - Department of Electrical and Computer Engineering [Albuquerque]
161 Division of Molecular and Cellular Therapeutics
162 SAMS - Scottish Association for Marine Science
163 Structural Biology Laboratory, Department of Chemistry, University of York
164 Neurology Division, Beaumont Hospital, Dublin 9, Ireland
165 Department of Neurology
166 Deparment of Medical Genetics
167 Human Genetics Branch
168 Athinoula A. Martinos Center for Biomedical Imaging
169 Department of Psychiatry, University of Iowa
170 Institute for Community Medicine, Department Epidemiology of Health Care and Community Health
171 Translational Centre for Regenerative Medicine (TRM); Department of Cell Therapy
172 Institute of Clinical Chemistry and Laboratory Medicine
173 Department of Health Science, Division of Health and Rehabilitation
174 Stanley Center for Psychiatric Research
175 Psychiatric and Neurodevelopmental Genetics Unit
176 849 Department of Human Genetics
177 Institute for Community Medicine
178 Institute for Energy Systems and Thermodynamics
179 Renyi Institute
180 Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, NSW
181 Department of Child and Adolescent Psychiatry, Erasmus University Medical Centre, Rotterdam 3000 CB, The Netherlands
182 Department of Radiology, Erasmus University Medical Centre, Rotterdam 3015 CN, The Netherlands
183 VU - Vrije Universiteit Amsterdam [Amsterdam]
184 Cell Biology and Gene Expression Section
185 Dept of Psychology
186 Laboratoire de Recherche Magellan
187 ISEOR - Institut de Socio-économie des Entreprises et des ORganisations
188 Department of Psychiatry and Psychotherapy
189 LIG - Laboratoire d'Informatique de Grenoble
190 Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development,
191 Centre for Allergy Research
192 Department of Medicine, Clinical Pharmacology Unit
193 MUL - Medical University of Łódź
194 Psychiatry Institute
195 Department of Health and Human Services
196 Institute of Gerontology and Geriatrics
197 CSIRO - Commonwealth Scientific and Industrial Research Organisation [Canberra]
198 Australian Centre for Research into Injury in Sport and its Prevention
199 Department of Psychiatry
200 School of Psychology [Nottingham]
201 MNI - McConnell Brain Imaging Centre
202 SickKids - The Hospital for sick children
203 Department of Medical and Molecular Genetics
204 ECMWF - European Centre for Medium-Range Weather Forecasts
205 Department of neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
206 Centre for Population Health Sciences
207 LIBD - Lieber Institute for Brain Development [Baltimore]
208 JHU - Johns Hopkins University
209 Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique
210 Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz 8010, Austria
211 AIT - Austrian Institute of Technology [Vienna]
212 INSERM Research Center for Epidemiology and Biostatistics (U897) Team Neuroepidemiology, Bordeaux, France College of Health Sciences, University of Bordeaux, Bordeaux, France
213 INSERM, Neuroepidemiology U708, Bordeaux, France
214 KIT - Karlsruhe Institute of Technology
215 General Internal Medicine, Johns Hopkins School of Medicine
216 Erasmus MC - Erasmus University Medical Center [Rotterdam]
217 HMS - Harvard Medical School [Boston]
218 CSAIL - Computer Science and Artificial Intelligence Laboratory [Cambridge]
219 University of Washington [Seattle]
220 Department of Physics [Stockholm]
221 Department of Neurology
222 Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands
223 Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands
224 BU - Boston University [Boston]
225 GIN - UMR 5296 - Groupe d'Imagerie Neurofonctionnelle
226 Faculty of Medicine
227 Icelandic Heart Association, Kopavogur, Iceland.
228 BUSM - Boston University School of Medicine
229 LIMATB - Laboratoire d'Ingénierie des Matériaux de Bretagne
230 School of Psychology, University of Queensland, Brisbane 4072, Australia
231 BROAD INSTITUTE - Broad Institute of MIT and Harvard
Roberto Toro
- Function : Author
- PersonId : 172082
- IdHAL : robertotoro
- ORCID : 0000-0002-6671-858X
- IdRef : 089439317
Sungeun Kim
- Function : Author
Marieke Klein
- Function : Author
Emma Sprooten
- Function : Author
Marcella Rietschel
- Function : Author
- PersonId : 757743
- ORCID : 0000-0002-5236-6149
Francis J Mcmahon
- Function : Author
René S Kahn
- Function : Author
Bertram Müller-Myhsok
- Function : Author
- PersonId : 763103
- ORCID : 0000-0002-0719-101X
- IdRef : 152975233
Hilkka Soininen
- Function : Author
- PersonId : 763717
- ORCID : 0000-0002-2785-9937
Bernard Mazoyer
- Function : Author
- PersonId : 757140
- ORCID : 0000-0003-0970-2837
- IdRef : 059391170
Abstract
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.