This paper presents the analytical framework developed iteratively by the research team of the Chance2Sustain (C2S) research project between 2010 and July 2014, in order to answer the main research question which was posed at the outset of the research, namely : how can spatial knowledge management (SKM) and participatory governance contribute to sustainable urban development ? To answer this question, the C2S project was designed to undertake comparative empirical research in 10 cities in four fast-growing countries of the South to understand the role of SKM and participatory processes in facing the challenges in a number of strategic domains of urban development ; those of economic growth, social inequality and vulnerability, and environmental governance. In each city, there were researchers from both the North and South working together in the five domains of economic growth through megaprojects ; social mobilisation and social exclusion in sub-standard settlements ; environmental governance with the focus on water-related issues ; spatial knowledge management; and fiscal decentralisation and participatory city budgeting.