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Article Dans Une Revue Neurobiology of Aging Année : 2014

Hippocampal perivascular spaces are related to aging and blood pressure but not to cognition.

Résumé

The risk factors of hippocampal dilated perivascular spaces (H-dPVS), their radiological relevance and their impact on cognitive performance remain under investigation. These aspects were evaluated in 1818 stroke- and dementia-free participants enrolled in the 3C-Dijon MRI study, using logistic regression, multiple linear regression, and Cox models. At study entry, the load of H-dPVS was found strongly associated with age and hypertension (degree 2 vs. degree 0: odds ratio: 1.16; 95% confidence interval: 1.02-1.33 and odds ratio: 1.98; 95% confidence interval: 1.39-2.81, respectively) and positively related to the presence of lacunar infarcts, white-matter hyperintensities volume, and hippocampal volume (p ≤ 0.024). Load of H-dPVS was not related to baseline cognitive performance (p > 0.05). Cox regression modeling did not show a significant relationship between the load of H-dPVS and incident dementia risk (p > 0.05). The present results support that both aging and blood pressure do play a key role in the development of H-dPVS in the older population. In contrast with the dilated perivascular spaces located in white matter or basal ganglia, the load of H-dPVS does not appear associated with occurrence of dementia.

Domaines

Neurosciences
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Dates et versions

hal-01196128 , version 1 (11-09-2015)

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Ming Yao, Yi-Cheng Zhu, Aïcha Soumaré, Carole Dufouil, Bernard Mazoyer, et al.. Hippocampal perivascular spaces are related to aging and blood pressure but not to cognition.. Neurobiology of Aging, 2014, 35 (9), pp.2118-25. ⟨10.1016/j.neurobiolaging.2014.03.021⟩. ⟨hal-01196128⟩
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