Potencial terapéutico del [i]Hibiscus sabdariffa[/i]: una revisión de las evidencias científicas - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición Année : 2014

Potencial terapéutico del [i]Hibiscus sabdariffa[/i]: una revisión de las evidencias científicas

Résumé

[b]Background and objective:[/b] Infusion of [i]Hibiscus sabdariffa (H. sabdariffa[/i]) is a very popular drink in many parts of the world. Its phytochemical composition is associated to antioxidant, hypotensive, and antiatherosclerotic effects. However, the molecular mechanisms involved in these processes are not well known. The aim of this review was to report the scientific evidence supporting that regular use of [i]H. sabdariffa[/i] decreases oxidative stress, atherosclerosis, lipid profile, and blood pressure.[br/] [b]Materials and methods:[/b] A search of recent publications was made in the following specialized electronic databases: Elsevier Journal, SciELO, FSTA, Science Direct, Springer Link, and NCBI. Results of research conducted in clinical trials in humans and in animal models and cell cultures were recorded. Keywords used included Hibiscus sabdariffa, oxidative stress, polyphenols, hypertension, atherosclerosis, and lipid profile.[br/] [b]Results:[/b] Results of the different articles suggested a possible therapeutic effect of[i] H. sabdariffa[/i] extracts on oxidative stress, lipid profile, hypertension, and atherosclerosis thanks to its composition rich in phenolic compounds. Anthocyanins significantly decrease LDL oxidation, inhibit adipogenesis by regulating adipogenic signaling pathways and transcription factors, and modulate gene expression of certain microRNAs. No adverse events or side effects were reported.[br/] [b]Conclusions:[/b] Further more homogeneous, placebo-controlled studies in humans are needed to state that [i]H. sabdariffa[/i] has therapeutic efficacy in humans.
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Dates et versions

hal-01193876 , version 1 (04-09-2015)

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Citer

Soledad Guardiola, Núria Mach. Potencial terapéutico del [i]Hibiscus sabdariffa[/i]: una revisión de las evidencias científicas. Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición, 2014, 61 (5), pp.274-295. ⟨10.1016/j.endonu.2013.10.012⟩. ⟨hal-01193876⟩
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