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Article Dans Une Revue Neuropeptides Année : 2014

Expression profile of hypothalamic neuropeptides in chicken lines selected for high or low residual feed intake.

Résumé

The R+ and R- chicken lines have been divergently selected for high (R+) or low (R-) residual feed intake. For the same body weight and egg production, the R+ chickens consume 40% more food than their counterparts R- lines. In the present study we sought to determine the hypothalamic expression profile of feeding-related neuropeptides in these lines maintained under fed or food-deprived conditions. In the fed condition, the suppressor of cytokine signaling 3 (SOCS3) was 17-fold lower (P < 0.05) and the ghrelin receptor was 7-fold higher (P < 0.05) in R+ compared to R- chicken lines. The hypothalamic expression of the other studied genes remained unchanged between the two lines. In the fasted state, orexigenic neuropeptide Y and agouti-related peptide were more responsive, with higher significant levels in the le compared to R- chickens, while no significant differences were seen for the anorexigenic neuropeptides pro-opiomelanocortin and corticotropin releasing hormone. Interestingly, C-reactive protein, adiponectin receptor 1 and ghrelin receptor gene expression were significantly higher (12-, 2- and 3-folds, respectively), however ghrelin and melanocortin 5 receptor mRNA levels were lower (4- and 2-folds, P = 0.05 and P = 0.03, respectively) in R+ compared to R- animals. We identified several key feeding-related genes that are differently expressed in the hypothalamus of R+ and R- chickens and that might explain the difference in feed intake observed between the two lines.
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Dates et versions

hal-01193827 , version 1 (04-09-2015)

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P. Sintubin, E. Greene, Anne Collin, Andre Bordas, Tatiana Zerjal, et al.. Expression profile of hypothalamic neuropeptides in chicken lines selected for high or low residual feed intake.. Neuropeptides, 2014, 48 (4), pp.213-220. ⟨10.1016/j.npep.2014.04.007⟩. ⟨hal-01193827⟩
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