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Article Dans Une Revue Biochemical and Biophysical Research Communications Année : 2009

R-spondin1 is required for normal epithelial morphogenesis during mammary gland development

Résumé

The R-spondin (Rspo) proteins constitute a novel class of ligands that induce Wnt signalling. Rspo1 knockout XX mice were previously shown to be sex-reversed, but some remain sub-fertile. These last were unable to feed their pups for some unknown reason. Using these mice and transplanted mammary tissues from Rspo1−/− virgin mice in nude mice, we report that the lack of Rspo1 expression results in the absence of duct side-branching development and subsequent alveolar formation, explaining the above mentioned phenotype. Our data demonstrate that local epithelial Rspo1 signalling is required for normal development of the mammary gland.

Dates et versions

hal-01193559 , version 1 (04-09-2015)

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Citer

Sead Chadi, Laurine Buscara, Isabelle Pechoux, Jose Costa, Johann Laubier, et al.. R-spondin1 is required for normal epithelial morphogenesis during mammary gland development. Biochemical and Biophysical Research Communications, 2009, 390 (3), pp.1040-1043. ⟨10.1016/j.bbrc.2009.10.104⟩. ⟨hal-01193559⟩
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