<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01191263</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-24T15:58:26+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Identification and characterization of MYB-bHLH-WD40 regulatory complexes controlling proanthocyanidin biosynthesis in strawberry (Fragaria 9 ananassa) fruits</title>
            <author role="aut">
              <persName>
                <forename type="first">Jan G.</forename>
                <surname>Schaart</surname>
              </persName>
              <idno type="halauthorid">936863-0</idno>
              <affiliation ref="#struct-429068"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christian</forename>
                <surname>Dubos</surname>
              </persName>
              <email type="md5">3322795b3acc8279461be3912797b3ba</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="numeric">770362</idno>
              <idno type="halauthorid" notation="string">787702-770362</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5486-3643</idno>
              <idno type="IDREF">https://www.idref.fr/059834579</idno>
              <affiliation ref="#struct-10916"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Irene</forename>
                <surname>Romeo de La Fuente</surname>
              </persName>
              <idno type="halauthorid">936864-0</idno>
              <affiliation ref="#struct-429068"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Adèle M.M.L.</forename>
                <surname>van Houwelingen</surname>
              </persName>
              <idno type="halauthorid">936865-0</idno>
              <affiliation ref="#struct-429069"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Ric C.H.</forename>
                <surname>de Vos</surname>
              </persName>
              <idno type="halauthorid">936866-0</idno>
              <affiliation ref="#struct-429070"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Harry H.</forename>
                <surname>Jonker</surname>
              </persName>
              <idno type="halauthorid">936867-0</idno>
              <affiliation ref="#struct-429070"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Wenjia</forename>
                <surname>Xu</surname>
              </persName>
              <email type="md5">7f3100154c98414c19ecfdf39059bff3</email>
              <email type="domain">inra.fr</email>
              <idno type="idhal" notation="numeric">1314099</idno>
              <idno type="halauthorid" notation="string">787691-1314099</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1945-4451</idno>
              <affiliation ref="#struct-10916"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Marc</forename>
                <surname>Routaboul</surname>
              </persName>
              <email type="md5">860d4e747e5087b76b5bd3b7bcaca4c2</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">jean-marc-routaboul</idno>
              <idno type="idhal" notation="numeric">1260425</idno>
              <idno type="halauthorid" notation="string">787701-1260425</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2197-5280</idno>
              <idno type="GOOGLE SCHOLAR">NIKZjd8AAAAJ</idno>
              <affiliation ref="#struct-10916"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Loic</forename>
                <surname>Lepiniec</surname>
              </persName>
              <email type="md5">0b46c9c169a926c32ba4615383be656b</email>
              <email type="domain">inrae.fr</email>
              <idno type="idhal" notation="string">loic-lepiniec</idno>
              <idno type="idhal" notation="numeric">736393</idno>
              <idno type="halauthorid" notation="string">32347-736393</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-5808-2012</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5845-3323</idno>
              <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=v5xXwzYAAAAJ&amp;hl=en</idno>
              <idno type="IDREF">https://www.idref.fr/084326727</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-5808-2012</idno>
              <affiliation ref="#struct-10916"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Arnaud G.</forename>
                <surname>Bovy</surname>
              </persName>
              <idno type="halauthorid">936868-0</idno>
              <affiliation ref="#struct-429071"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Archive Ouverte</forename>
                <surname>ProdInra</surname>
              </persName>
              <email type="md5">9e5ed7d56b52b3d4383123b1ffb42236</email>
              <email type="domain">inrae.fr</email>
            </editor>
            <funder>China Scholarship Council (CSC)</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-05-29 15:54:48</date>
              <date type="whenModified">2026-05-13 16:40:43</date>
              <date type="whenReleased">2020-05-29 15:54:55</date>
              <date type="whenProduced">2013</date>
              <date type="whenEndEmbargoed">2020-05-29</date>
              <ref type="file" target="https://hal.science/hal-01191263v1/document">
                <date notBefore="2020-05-29"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-01191263v1/file/nph12017_1.pdf" id="file-2651232-2468369">
                <date notBefore="2020-05-29"/>
              </ref>
              <fs>
                <f name="inra_publicVise_local" notation="string" n="SC">
                  <string>inra_publicVise_local_SC</string>
                </f>
              </fs>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="132775">
                <persName>
                  <forename>Archive Ouverte</forename>
                  <surname>ProdInra</surname>
                </persName>
                <email type="md5">9e5ed7d56b52b3d4383123b1ffb42236</email>
                <email type="domain">inrae.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01191263</idno>
            <idno type="halUri">https://hal.science/hal-01191263</idno>
            <idno type="halBibtex">schaart:hal-01191263</idno>
            <idno type="halRefHtml">&lt;i&gt;New Phytologist&lt;/i&gt;, 2013, 197 (2), pp.454-467. &lt;a target="_blank" href="https://dx.doi.org/10.1111/nph.12017"&gt;&amp;#x27E8;10.1111/nph.12017&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">New Phytologist, 2013, 197 (2), pp.454-467. &amp;#x27E8;10.1111/nph.12017&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2651232-2468369"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="AGROPARISTECH">AgroParisTech</idno>
            <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno>
            <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno>
            <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno>
            <idno type="stamp" n="IJPB">UMR 1318 -  Institut Jean Pierre Bourgin for plant Sciences</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="1">Not set</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Identification and characterization of MYB-bHLH-WD40 regulatory complexes controlling proanthocyanidin biosynthesis in strawberry (Fragaria 9 ananassa) fruits</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Jan G.</forename>
                    <surname>Schaart</surname>
                  </persName>
                  <idno type="halauthorid">936863-0</idno>
                  <affiliation ref="#struct-429068"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christian</forename>
                    <surname>Dubos</surname>
                  </persName>
                  <email type="md5">3322795b3acc8279461be3912797b3ba</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="numeric">770362</idno>
                  <idno type="halauthorid" notation="string">787702-770362</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5486-3643</idno>
                  <idno type="IDREF">https://www.idref.fr/059834579</idno>
                  <affiliation ref="#struct-10916"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Irene</forename>
                    <surname>Romeo de La Fuente</surname>
                  </persName>
                  <idno type="halauthorid">936864-0</idno>
                  <affiliation ref="#struct-429068"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Adèle M.M.L.</forename>
                    <surname>van Houwelingen</surname>
                  </persName>
                  <idno type="halauthorid">936865-0</idno>
                  <affiliation ref="#struct-429069"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Ric C.H.</forename>
                    <surname>de Vos</surname>
                  </persName>
                  <idno type="halauthorid">936866-0</idno>
                  <affiliation ref="#struct-429070"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Harry H.</forename>
                    <surname>Jonker</surname>
                  </persName>
                  <idno type="halauthorid">936867-0</idno>
                  <affiliation ref="#struct-429070"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Wenjia</forename>
                    <surname>Xu</surname>
                  </persName>
                  <email type="md5">7f3100154c98414c19ecfdf39059bff3</email>
                  <email type="domain">inra.fr</email>
                  <idno type="idhal" notation="numeric">1314099</idno>
                  <idno type="halauthorid" notation="string">787691-1314099</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1945-4451</idno>
                  <affiliation ref="#struct-10916"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Marc</forename>
                    <surname>Routaboul</surname>
                  </persName>
                  <email type="md5">860d4e747e5087b76b5bd3b7bcaca4c2</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">jean-marc-routaboul</idno>
                  <idno type="idhal" notation="numeric">1260425</idno>
                  <idno type="halauthorid" notation="string">787701-1260425</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2197-5280</idno>
                  <idno type="GOOGLE SCHOLAR">NIKZjd8AAAAJ</idno>
                  <affiliation ref="#struct-10916"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Loic</forename>
                    <surname>Lepiniec</surname>
                  </persName>
                  <email type="md5">0b46c9c169a926c32ba4615383be656b</email>
                  <email type="domain">inrae.fr</email>
                  <idno type="idhal" notation="string">loic-lepiniec</idno>
                  <idno type="idhal" notation="numeric">736393</idno>
                  <idno type="halauthorid" notation="string">32347-736393</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/G-5808-2012</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5845-3323</idno>
                  <idno type="GOOGLE SCHOLAR">https://scholar.google.fr/citations?user=v5xXwzYAAAAJ&amp;hl=en</idno>
                  <idno type="IDREF">https://www.idref.fr/084326727</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/G-5808-2012</idno>
                  <affiliation ref="#struct-10916"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Arnaud G.</forename>
                    <surname>Bovy</surname>
                  </persName>
                  <idno type="halauthorid">936868-0</idno>
                  <affiliation ref="#struct-429071"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">17445</idno>
                <idno type="issn">0028-646X</idno>
                <idno type="eissn">1469-8137</idno>
                <title level="j">New Phytologist</title>
                <imprint>
                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">197</biblScope>
                  <biblScope unit="issue">2</biblScope>
                  <biblScope unit="pp">454-467</biblScope>
                  <date type="datePub">2013</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1111/nph.12017</idno>
              <idno type="prodinra">172546</idno>
              <idno type="wos">000313265600016</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">bHLH</term>
                <term xml:lang="en">flavonoid biosynthesis</term>
                <term xml:lang="en">MYB</term>
                <term xml:lang="en">strawberry (Fragaria9ananassa)</term>
                <term xml:lang="en">WD40-repeat</term>
                <term xml:lang="en">yeast-two-hybrid</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="vocinrae-old" n="biosynthèse">biosynthèse</classCode>
              <classCode scheme="vocinrae-old" n="flavanoïde">flavanoïde</classCode>
              <classCode scheme="vocinrae-old" n="fragaria ananassa">fragaria ananassa</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Strawberry (Fragaria 9 ananassa) fruits contain high concentrations of flavonoids. In unripe strawberries, the flavonoids are mainly represented by proanthocyanidins (PAs), while in ripe fruits the red-coloured anthocyanins also accumulate. Most of the structural genes leading to PA biosynthesis in strawberry have been characterized, but no information is available on their transcriptional regulation. In Arabidopsis thaliana the expression of the PA biosynthetic genes is specifically induced by a ternary protein complex, composed of AtTT2 (AtMYB123), AtTT8 (AtbHLH042) and AtTTG1 (WD40-repeat protein). A strategy combining yeast-two-hybrid screening and agglomerative hierarchical clustering of transcriptomic and metabolomic data was undertaken to identify strawberry PA regulators.   Among the candidate genes isolated, four were similar to AtTT2, AtTT8 and AtTTG1 (FaMYB9/FaMYB11, FabHLH3 and FaTTG1, respectively) and two encode putative negative regulators (FaMYB5 and FabHLH3Δ). Interestingly, FaMYB9/FaMYB11, FabHLH3 and FaTTG1 were found to complement the tt2-1, tt8-3 and ttg1-1 transparent testa mutants, respectively. In addition, they interacted in yeast and activated the Arabidopsis BANYULS (anthocyanidin reductase) gene promoter when coexpressed in Physcomitrella patens protoplasts. Taken together, these results demonstrated that FaMYB9/FaMYB11, FabHLH3 and FaTTG1 are the respective functional homologues of AtTT2, AtTT8 and AtTTG1, providing new tools for modifying PA content and strawberry fruit quality.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-429068" status="INCOMING">
          <orgName>Wageningen UR Plant Breeding</orgName>
          <desc>
            <address>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-356395" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-10916" status="OLD">
          <idno type="IdRef">156970740</idno>
          <idno type="RNSR">201119640E</idno>
          <idno type="ROR">https://ror.org/01wqd6v19</idno>
          <orgName>Institut Jean-Pierre Bourgin</orgName>
          <orgName type="acronym">IJPB</orgName>
          <date type="start">2010-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>INRA Centre de Versailles-Grignon, Route de St-Cyr (RD10), 78026 Versailles Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR1318" active="#struct-92114" type="direct"/>
            <relation active="#struct-148117" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-429069" status="INCOMING">
          <orgName>Plant Research International, Business Unit Bioscience</orgName>
          <desc>
            <address>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-356395" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-429070" status="INCOMING">
          <orgName>Plant Research International, Business Unit Bioscience, Centre for Biosystems Genomics</orgName>
          <desc>
            <address>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-356395" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-429071" status="INCOMING">
          <orgName>Wageningen UR Plant Breeding, Centre for Biosystems Genomics</orgName>
          <desc>
            <address>
              <country key="NL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-356395" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-356395" status="VALID">
          <idno type="ROR">https://ror.org/04qw24q55</idno>
          <orgName>Wageningen University and Research [Wageningen]</orgName>
          <orgName type="acronym">WUR</orgName>
          <desc>
            <address>
              <addrLine>Droevendaalsesteeg 4, 6708 PB Wageningen</addrLine>
              <country key="NL"/>
            </address>
            <ref type="url">http://www.wageningenur.nl/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-92114" status="OLD">
          <idno type="ROR">https://ror.org/01x3gbx83</idno>
          <orgName>Institut National de la Recherche Agronomique</orgName>
          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inra.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-148117" status="VALID">
          <idno type="IdRef">139408088</idno>
          <idno type="ROR">https://ror.org/02kbmgc12</idno>
          <orgName>AgroParisTech</orgName>
          <date type="start">2007-01-01</date>
          <desc>
            <address>
              <addrLine>22 place de l'Agronomie CS 20040 91123 Palaiseau cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.agroparistech.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>