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Article Dans Une Revue Médecine/Sciences Année : 2015

Fragment-based screening: a promising avenue for drug design

Résumé

Fragment bused screening is now recognised as a powerful method for the design of novel potent molecules against therapeutic protein targets including challenging targets, Here, the main concepts used in the fragment bused drug design approach are reviewed, together with the reasons for its success, Methods and strategies used to identify, validate and select fragments are discussed, Future challenges and developments that are expected for the next decade are presented,

Dates et versions

hal-01187367 , version 1 (26-08-2015)

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Citer

Isabelle Krimm. Fragment-based screening: a promising avenue for drug design. Médecine/Sciences, 2015, 31 (2), pp.197-202. ⟨10.1051/medsci/20153102017⟩. ⟨hal-01187367⟩
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