Systems biology aims at deciphering the functioning of biological systems on the basis of the knowledge of their molecular components and the relations between such components. To address the issues involved, high-throughput technologies are used. Taking advantage of the standards that are being currently developed to achieve consensual representations of technological domains, we present a metamodelling architecture based on these standards. The proposed architecture organises standard-specific metamodels and models into a single hierarchy. Each metamodel describes a consensus that is shared by several models of applications. A metamodel construct for description of faceted element is proposed together with this architecture.