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Article Dans Une Revue Chemistry - A European Journal Année : 2014

Mechanistic studies of Gd$^{3+}$-based MRI contrast agents for Zn$^{2+}$ detection: towards rational design

Célia S. Bonnet
Agnès Pallier
Jean-François Morfin
Stéphane Petoud
Franck Suzenet
Éva Tóth

Résumé

A series of novel pyridine-based Gd$^{3+}$ complexes have been prepared and studied as potential MRI contrast agents for Zn$^{2+}$ detection. By independent assessment of molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon Zn$^{2+}$ binding in terms of variations of the rotational motion.

Dates et versions

hal-01178456 , version 1 (20-07-2015)

Identifiants

Citer

Célia S. Bonnet, Fabien Caillé, Agnès Pallier, Jean-François Morfin, Stéphane Petoud, et al.. Mechanistic studies of Gd$^{3+}$-based MRI contrast agents for Zn$^{2+}$ detection: towards rational design. Chemistry - A European Journal, 2014, 20 (35), pp.10959-10969. ⟨10.1002/chem.201403043⟩. ⟨hal-01178456⟩
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