This paper presents our multi-agent framework (named CellInvasion) for modelling and predicting the emergent behaviour resulting from the presence of distinct environmental conditions that lead to bad interaction of cells in their tissue. As the migration of tumoural cells through the biologic gates constitutes the major dynamic event of tumoural invasion, the objective of CellInvasion is to be a virtual world of cellular biology while simulating the cellular behaviour specially the migratory behaviour in order to help its specialists to better understand, to good interpret and to warn changes of cell states according to its actual internal state and to the state of its environment. The Architecture of CellInvasion is composed of a set of reactive agents. These agents use an ontology (named OntoCell) to communicate and to represent their knowledge. OntoCell describes the knowledge of cellular biology. CellInvasion is implemented with a multi-agent platform (named DIMA).