The antitumor effects of an arsthinol–cyclodextrin complex in a heterotopic mouse model of glioma - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Pharmaceutics and Biopharmaceutics Année : 2013

The antitumor effects of an arsthinol–cyclodextrin complex in a heterotopic mouse model of glioma

Résumé

In this paper, we examined arsthinol–cyclodextrin complexes, which display an anticancer activity. The association constants were 17,502 ± 522 M À1 for hydroxypropyl-b-cyclodextrin and 12,038 ± 10,168 M À1 for randomized methylated b-cyclodextrin. 1 H NMR experiments in solution also confirmed the formation of these complexes and demonstrated an insertion of the arsthinol (STB) with its dithiarsolane extremity into the wide rim of the hydroxypropyl-b-cyclodextrin cavity. Complexed arsthinol was more effective than arsenic trioxide (As 2 O 3) and melarsoprol on the U87 MG cell line. Importantly, in the in vivo study, we observed significant antitumor activity against heterotopic xenografts after i.p. administration and did not see any signs of toxicity. This remains to be verified using an orthotopic model.
Fichier principal
Vignette du fichier
Eur J Pharm Biopharm 2013 Becherirat.pdf (1.76 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01169157 , version 1 (05-07-2015)

Identifiants

Citer

Selma Becherirat, Marie-Claire Lanhers, Marie Socha, Mehdi Yemloul, Alain Astier, et al.. The antitumor effects of an arsthinol–cyclodextrin complex in a heterotopic mouse model of glioma. European Journal of Pharmaceutics and Biopharmaceutics, 2013, 83 (3 Pt A), pp.560-568. ⟨10.1016/j.ejpb.2013.06.021⟩. ⟨hal-01169157⟩
111 Consultations
270 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More