A mild titanium-based system for the reduction of amides to aldehydes - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Tetrahedron Année : 2010

A mild titanium-based system for the reduction of amides to aldehydes

Résumé

A mild method for the reduction of amides to aldehydes using 1,1,3,3-tetramethyldisiloxane/titanium(IV) isopropoxide reducing system is described. The reaction occurs under mild conditions and allows the reduction of aromatic as well as aliphatic, tertiary amides to the corresponding aldehydes, in good yields. This methodology was extended to the reduction of aromatic secondary and primary amides to the corresponding aldehydes.

Domaines

Chimie organique

Dates et versions

hal-01166779 , version 1 (23-06-2015)

Identifiants

Citer

Stéphane Laval, Wissam Dayoub, Alain Favre-Reguillon, Patrice Demonchaux, Gérard Mignani, et al.. A mild titanium-based system for the reduction of amides to aldehydes. Tetrahedron, 2010, 51 (16), pp.2092-2094. ⟨10.1016/j.tetlet.2010.02.008⟩. ⟨hal-01166779⟩
94 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More