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Article Dans Une Revue Tetrahedron Letters Année : 2009

A mild and efficient method for the reduction of nitrile.

Résumé

A simple and useful method for the reduction of nitriles into the corresponding amines using a tetramethyldisiloxane/titanium(IV) isopropoxide reducing system is described. The synthetic approach is straightforward and provides primary amines as hydrochloride salt in almost quantitative yield. Other advantages of this method, such as easy-to-handle hydride source, inert by-products, that is, TiO2 and oligomeric siloxanes, make it very attractive to prepare primary amines.

Domaines

Chimie organique

Dates et versions

hal-01166202 , version 1 (22-06-2015)

Identifiants

Citer

Stéphane Laval, Wissam Dayoub, Alain Favre-Reguillon, Mikaël Berthod, Patrice Demonchaux, et al.. A mild and efficient method for the reduction of nitrile.. Tetrahedron Letters, 2009, 50, pp.7005-7007. ⟨10.1016/j.tetlet.2009.09.164⟩. ⟨hal-01166202⟩
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