Diastereoselective conjugate addition of (R)-4-phenyl-2-oxazolidinone to dialkyl alkylidenemalonates
Résumé
The addition of the potassium salt of (R)-4-phenyl-2-oxazolidinone to dialkyl alkylidenemalonates under various conditions is reported. Very good diastereoselectivities (> 90% de) were obtained in several cases. Conversion of one of the adducts to the β-amino acid (S)-β-leucine was achieved in two straightforward steps.
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