Diastereoselective conjugate addition of (R)-4-phenyl-2-oxazolidinone to dialkyl alkylidenemalonates - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ARKIVOC - Online Journal of Organic Chemistry Année : 2015

Diastereoselective conjugate addition of (R)-4-phenyl-2-oxazolidinone to dialkyl alkylidenemalonates

Résumé

The addition of the potassium salt of (R)-4-phenyl-2-oxazolidinone to dialkyl alkylidenemalonates under various conditions is reported. Very good diastereoselectivities (> 90% de) were obtained in several cases. Conversion of one of the adducts to the β-amino acid (S)-β-leucine was achieved in two straightforward steps.
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Dates et versions

hal-01157633 , version 1 (17-11-2015)

Identifiants

  • HAL Id : hal-01157633 , version 1

Citer

Julien Capra, Bo Gao, Hélène Hemmery, Pierre Thuéry, Thierry Le Gall. Diastereoselective conjugate addition of (R)-4-phenyl-2-oxazolidinone to dialkyl alkylidenemalonates. ARKIVOC - Online Journal of Organic Chemistry, 2015, pp.60-70. ⟨hal-01157633⟩
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