A FRET-​based probe for fluorescence sensing of sulfide​/sulfite analytes, using a novel long-​wavelength water-​soluble 7-​hydroxycoumarin as reporter fluorophore - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Tetrahedron Letters Année : 2015

A FRET-​based probe for fluorescence sensing of sulfide​/sulfite analytes, using a novel long-​wavelength water-​soluble 7-​hydroxycoumarin as reporter fluorophore

Résumé

A FRET-based fluorescent probe for the detection of sulfide and/or sulfite in aqueous buffer, was constructed by connecting the quencher moiety nitrobenzofurazan (7-nitro-1,2,3-benzoxadiazole, NBD) to a water-soluble 3-(2-benzimidazolyl)-7-hydroxycoumarin carboxylic acid through a piperazine linker. This probe exhibits good selectivity and high sensitivity for sulfite and sulfide over cysteine and other potential analytes. Furthermore, this is one of the few examples of fluorogenic coumarins whose solubility in water is maintained upon its conversion into reaction-based fluorescent probes.
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Dates et versions

hal-01150270 , version 1 (10-05-2015)

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Benoît Roubinet, Laëtitia Bailly, Emilie Petit, Pierre-Yves Renard, Anthony Romieu. A FRET-​based probe for fluorescence sensing of sulfide​/sulfite analytes, using a novel long-​wavelength water-​soluble 7-​hydroxycoumarin as reporter fluorophore. Tetrahedron Letters, 2015, 56 (8), pp.1015-1019. ⟨10.1016/j.tetlet.2015.01.042⟩. ⟨hal-01150270⟩
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