[18F]CuCF3 :A[18F]Trifluoromethylating Agent for Arylboronic Acids and Aryl Iodides - Archive ouverte HAL
Article Dans Une Revue Chemistry - A European Journal Année : 2014

[18F]CuCF3 :A[18F]Trifluoromethylating Agent for Arylboronic Acids and Aryl Iodides

Résumé

Positron emission tomography has emerged as the leading method for medical imaging with fluorine‐18 as the most widely used radioactive isotope. Here we report a semi‐automated method for the preparation of valuable [18F]trifluoromethylcopper, as well as its use for the radiosynthesis of [18F]trifluoromethylarenes and heteroarenes. Mild conditions of [18F]trifluoromethylation make this method particularly useful for the radiosynthesis of pharmacologically relevant [18F]trifluoromethylarenes and heteroarenes.

Dates et versions

hal-01149583 , version 1 (07-05-2015)

Identifiants

Citer

Pavel Ivashkin, Gérald Lemonnier, Jonathan Cousin, Vincent Grégoire, Daniel Labar, et al.. [18F]CuCF3 :A[18F]Trifluoromethylating Agent for Arylboronic Acids and Aryl Iodides. Chemistry - A European Journal, 2014, 20 (31), pp.9514-9518. ⟨10.1002/chem.201403630⟩. ⟨hal-01149583⟩
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