[18F]CuCF3 :A[18F]Trifluoromethylating Agent for Arylboronic Acids and Aryl Iodides
Résumé
Positron emission tomography has emerged as the leading method for medical imaging with fluorine‐18 as the most widely used radioactive isotope. Here we report a semi‐automated method for the preparation of valuable [18F]trifluoromethylcopper, as well as its use for the radiosynthesis of [18F]trifluoromethylarenes and heteroarenes. Mild conditions of [18F]trifluoromethylation make this method particularly useful for the radiosynthesis of pharmacologically relevant [18F]trifluoromethylarenes and heteroarenes.